轻度创伤性脑损伤后区域性大脑老化和萎缩的显著加速。
Significant Acceleration of Regional Brain Aging and Atrophy After Mild Traumatic Brain Injury.
机构信息
Ethel Percy Andrus Gerontology Center, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Corwin D. Denney Research Center, Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2023 Aug 2;78(8):1328-1338. doi: 10.1093/gerona/glad079.
Brain regions' rates of age-related volumetric change after traumatic brain injury (TBI) are unknown. Here, we quantify these rates cross-sectionally in 113 persons with recent mild TBI (mTBI), whom we compare against 3 418 healthy controls (HCs). Regional gray matter (GM) volumes were extracted from magnetic resonance images. Linear regression yielded regional brain ages and the annualized average rates of regional GM volume loss. These results were compared across groups after accounting for sex and intracranial volume. In HCs, the steepest rates of volume loss were recorded in the nucleus accumbens, amygdala, and lateral orbital sulcus. In mTBI, approximately 80% of GM structures had significantly steeper rates of annual volume loss than in HCs. The largest group differences involved the short gyri of the insula and both the long gyrus and central sulcus of the insula. No significant sex differences were found in the mTBI group, regional brain ages being the oldest in prefrontal and temporal structures. Thus, mTBI involves significantly steeper regional GM loss rates than in HCs, reflecting older-than-expected regional brain ages.
颅脑损伤（TBI）后与年龄相关的脑区容积变化率尚不清楚。本研究通过对 113 例近期轻度 TBI（mTBI）患者和 3418 例健康对照者（HCs）进行横断面对比，定量评估了这些变化率。从磁共振图像中提取了区域灰质（GM）体积。线性回归得出了区域脑龄和 GM 体积每年平均损失率。在考虑了性别和颅内体积后，对各组间的结果进行了比较。在 HCs 中，核仁、杏仁核和外侧眶回的体积丢失率最大。在 mTBI 中，大约 80%的 GM 结构的年体积损失率明显高于 HCs。最大的组间差异涉及脑岛短回和脑岛长回和中央沟。mTBI 组中未发现明显的性别差异，前额叶和颞叶结构的区域脑龄最大。因此，mTBI 患者的 GM 损失率明显高于 HCs，反映出比预期更老的区域脑龄。
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