University of Health Sciences, Istanbul, Turkey.
Bezmialem Vakif University, Istanbul, Turkey.
J Atten Disord. 2023 Jun;27(8):880-886. doi: 10.1177/10870547231159907. Epub 2023 Mar 6.
This study aims that oxidative stress and inflammation status in children and adolescents with attention deficit hyperactivity disorder (ADHD) compared to their healthy peers.
Thirty ADHD and healthy controls were included in this study. ADHD diagnosis according to the DSM-V and Conners' teacher and parent rating scale by a structured psychiatric interview. Total oxidant status (TOS), total antioxidant status (TAS), and total and native thiol levels were determined using photometric methods. Presepsin, Interleukin (IL) 1-ß, IL-6, and Tumor Necrosis Factor-alpha (TNF-α) levels were measured with commercial ELISA kits.
We showed that TOS and oxidative stress index were significantly higher in the ADHD group, and TAS was lower than in the control group (<.001). Similarly, IL1-ß, IL-6, and TNF-α levels were statistically higher in the ADHD group. Backward LR regression analysis reveals that TOS and IL-6 predicted ADHD.
TOS and IL-6 levels may play a role in the pathogenesis of ADHD.
本研究旨在比较儿童和青少年注意缺陷多动障碍（ADHD）与健康对照组的氧化应激和炎症状态。
本研究纳入了 30 名 ADHD 患儿和健康对照者。ADHD 的诊断依据 DSM-V 和康纳斯教师和家长评定量表，采用结构化精神科访谈。采用光比色法测定总氧化剂状态（TOS）、总抗氧化状态（TAS）、总巯基和天然巯基水平。采用商业 ELISA 试剂盒测定内脂素、白细胞介素（IL）1-β、IL-6 和肿瘤坏死因子-α（TNF-α）的水平。
我们发现 ADHD 组的 TOS 和氧化应激指数显著升高，而 TAS 低于对照组（<.001）。同样，ADHD 组的 IL1-β、IL-6 和 TNF-α水平也显著升高。向后 LR 回归分析显示，TOS 和 IL-6 可预测 ADHD。
TOS 和 IL-6 水平可能在 ADHD 的发病机制中起作用。
