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Front Immunol. 2021 Jan 27;11:621931. doi: 10.3389/fimmu.2020.621931. eCollection 2020.
2
Chronic Disseminated Candidiasis During Hematological Malignancies: An Immune Reconstitution Inflammatory Syndrome With Expansion of Pathogen-Specific T Helper Type 1 Cells.血液系统恶性肿瘤期间的慢性播散性念珠菌病：一种伴有病原体特异性1型辅助性T细胞扩增的免疫重建炎症综合征。
J Infect Dis. 2020 May 11;221(11):1907-1916. doi: 10.1093/infdis/jiz688.
3
Understanding Pathogenesis and Care Challenges of Immune Reconstitution Inflammatory Syndrome in Fungal Infections.了解真菌感染中免疫重建炎症综合征的发病机制及护理挑战。
J Fungi (Basel). 2018 Dec 17;4(4):139. doi: 10.3390/jof4040139.
4
Pentraxin-3 polymorphisms and invasive mold infections in acute leukemia patients receiving intensive chemotherapy.接受强化化疗的急性白血病患者中五聚体蛋白3基因多态性与侵袭性霉菌感染
Haematologica. 2018 Nov;103(11):e527-e530. doi: 10.3324/haematol.2018.195453. Epub 2018 Jun 7.
5
Clinical Predictors of Liver Fibrosis in Patients With Chronic Hepatitis B Virus Infection From Children to Adults.从儿童到成人的慢性乙型肝炎病毒感染者肝纤维化的临床预测因素。
J Infect Dis. 2018 Apr 11;217(9):1408-1416. doi: 10.1093/infdis/jiy048.
6
Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda.慢性播散性念珠菌病和急性白血病：对生存和造血干细胞移植议程的影响。
Med Mal Infect. 2018 May;48(3):202-206. doi: 10.1016/j.medmal.2017.12.004. Epub 2018 Jan 4.
7
Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.个体间变异性以及基因对细菌和真菌细胞因子反应的影响。
Nat Med. 2016 Aug;22(8):952-60. doi: 10.1038/nm.4139. Epub 2016 Jul 4.
8
Allele-specific induction of IL-1β expression by C/EBPβ and PU.1 contributes to increased tuberculosis susceptibility.C/EBPβ和PU.1对IL-1β表达的等位基因特异性诱导作用导致结核病易感性增加。
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9
Involvement of IL-17A in preventing the development of deep-seated candidiasis from oropharyngeal infection.白细胞介素-17A参与预防口咽感染引发深部念珠菌病。
Microbes Infect. 2014 Aug;16(8):678-89. doi: 10.1016/j.micinf.2014.06.007. Epub 2014 Jun 27.
10
Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus.IL1A 和 IL1B 基因变异与 2009 年甲型 H1N1 流感病毒易感性相关。
BMC Immunol. 2013 Aug 8;14:37. doi: 10.1186/1471-2172-14-37.

白细胞介素-1β的功能性多态性与慢性播散性念珠菌病的免疫重建炎症综合征相关。

A Functional Polymorphism in IL-1B Is Associated With Immune Reconstitution Inflammatory Syndrome of Chronic Disseminated Candidiasis.

作者信息

Rammaert Blandine, Bochud Pierre-Yves, Brunel Anne-Sophie, Wojtowicz Agnieszka, Candon Sophie, Gallego Hernanz Maria Pilar, Lortholary Olivier

机构信息

Université de Paris Cité, APHP, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Centre d'Infectiologie Necker-Pasteur, Institut Imagine, Paris, France.

Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, CHUV, Lausanne, Switzerland.

出版信息

Open Forum Infect Dis. 2023 Feb 14;10(3):ofad078. doi: 10.1093/ofid/ofad078. eCollection 2023 Mar.

DOI:10.1093/ofid/ofad078
PMID:36879623
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9984983/
Abstract

We investigated single nucleotide polymorphisms (SNPs) possibly involved in immune reconstitution inflammatory syndrome of chronic disseminated candidiasis (IRIS-CDC) through a candidate gene approach and a prospective matched-control study. We found that an SNP located in interleukin-1B at rs1143627 was significantly associated with the risk of developing IRIS-CDC.

摘要

我们通过候选基因方法和前瞻性匹配对照研究，调查了可能与慢性播散性念珠菌病免疫重建炎症综合征（IRIS-CDC）相关的单核苷酸多态性（SNP）。我们发现，位于白细胞介素-1B基因rs1143627位点的一个SNP与发生IRIS-CDC的风险显著相关。