Yu Guo, Ma Haoming, Lv Weitao, Zhou Peiru, Liu Cuiqing
School of Nursing, Jinan University, No. 601, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province, China.
Division of Critical Care, The First Affiliated Hospital of Jinan, No. 613, West Huangpu Avenue, Tianhe District, Guangzhou City, Guangdong Province, China.
Heliyon. 2023 Feb 11;9(3):e13662. doi: 10.1016/j.heliyon.2023.e13662. eCollection 2023 Mar.
The relationship between the TIR and mortality may be influenced by the presence of diabetes and other glycemic indicators. The purpose of this study was to investigate the relationship between TIR and in-hospital mortality in diabetic and non-diabetic patients in ICU.
A total of 998 patients with severe diseases in the ICU were selected for this retrospective analysis. The TIR is defined as the percentage of time spent in the target blood glucose range of 3.9-10.0 mmol/L within 24 h. The relationship between TIR and in-hospital mortality in diabetic and non-diabetic patients was analyzed. The effect of glycemic variability was also analyzed.
The binary logistic regression model showed that there was a significant association between the TIR and the in-hospital death of severely ill non-diabetic patients. Furthermore, TIR≥70% was significantly associated with in-hospital death (OR = 0.581, P = 0.003). The study found that the coefficient of variation (CV) was significantly associated with the mortality of severely ill diabetic patients (OR = 1.042, P = 0.027).
Both diabetic and non-diabetic critically ill patients should control blood glucose fluctuations and maintain blood glucose levels within the target range, it may be beneficial in reducing mortality.
糖尿病及其他血糖指标的存在可能会影响血糖目标范围内时间（TIR）与死亡率之间的关系。本研究旨在探讨重症监护病房（ICU）中糖尿病患者和非糖尿病患者的TIR与院内死亡率之间的关系。
本回顾性分析共纳入998例ICU重症患者。TIR定义为24小时内血糖处于3.9 - 10.0 mmol/L目标范围内的时间百分比。分析糖尿病患者和非糖尿病患者的TIR与院内死亡率之间的关系。同时也分析了血糖变异性的影响。
二元逻辑回归模型显示，TIR与重症非糖尿病患者的院内死亡之间存在显著关联。此外，TIR≥70%与院内死亡显著相关（OR = 0.581，P = 0.003）。研究发现，变异系数（CV）与重症糖尿病患者的死亡率显著相关（OR = 1.042，P = 0.027）。
糖尿病和非糖尿病重症患者均应控制血糖波动，并将血糖水平维持在目标范围内，这可能有助于降低死亡率。
