Department of Biology, Faculty of Science, York University, Toronto, Canada.
Hypertension. 2023 May;80(5):936-944. doi: 10.1161/HYPERTENSIONAHA.122.19456. Epub 2023 Mar 7.
Hypertension is a multicause health challenge, and hydrogen sulfide (HS) is a multifunctional gasotransmitter. A critical pathologic role of endogenous HS deficiency in the development of hypertension was established 15 years ago based on animal studies, setting the stage for examining the wide spectrum of cardiovascular effects and the underlying molecular and cellular mechanisms of HS. We are also starting to gain a better understanding of the role of altered HS metabolism in human hypertension. The purpose of this article is to examine our current understanding of the roles played by HS in the development of hypertension in both animals and humans. Additionally, HS-based antihypertension therapeutic strategies are reviewed. Is HS at the root of hypertension and one of the solutions for the same? The probability is very high.
高血压是一种多病因的健康挑战，而硫化氢（HS）是一种多功能的气体信号分子。基于动物研究，15 年前确定了内源性 HS 缺乏在高血压发展中的关键病理作用，为研究 HS 的广泛心血管作用及其潜在的分子和细胞机制奠定了基础。我们也开始更好地理解 HS 代谢改变在人类高血压中的作用。本文的目的是检查我们目前对 HS 在动物和人类高血压发展中的作用的理解。此外，还回顾了基于 HS 的抗高血压治疗策略。HS 是否是高血压的根源之一，也是治疗高血压的方法之一？可能性非常高。
