Kwitko G M, Shin D H, Ahn B H, Hong Y J
Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201.
Am J Ophthalmol. 1987 Dec 15;104(6):591-4. doi: 10.1016/0002-9394(87)90169-3.
We studied the bilateral intraocular pressure lowering effect of long-term unilateral timolol maleate 0.5% in 30 patients in whom early primary open-angle glaucoma had recently been diagnosed. A significant intraocular pressure reduction was found in the untreated fellow eyes (21.9 mm Hg from 26.4 mm Hg at baseline) (P less than .001), as well as in the treated eyes (21.0 mm Hg from 28.5 mm Hg at baseline) (P less than .001). Fourteen patients (47%) showed a significant bilateral intraocular pressure reduction (P less than .001), with little difference between the treated (8.2 mm Hg) and the untreated eyes (7.7 mm Hg) (P greater than .8).
我们研究了30例近期诊断为早期原发性开角型青光眼患者长期单侧使用0.5%马来酸噻吗洛尔的双侧降眼压效果。未治疗的对侧眼眼压显著降低（从基线时的26.4 mmHg降至21.9 mmHg）（P<0.001），治疗眼眼压也显著降低（从基线时的28.5 mmHg降至21.0 mmHg）（P<0.001）。14例患者（47%）双侧眼压显著降低（P<0.001），治疗眼（8.2 mmHg）与未治疗眼（7.7 mmHg）之间差异不大（P>0.8）。
