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加热型烟草制品二手气溶胶暴露与日本当前非吸烟者呼吸系统症状之间的关系:一项横断面研究。

Association between exposure to secondhand aerosol from heated tobacco products and respiratory symptoms among current non-smokers in Japan: a cross-sectional study.

机构信息

Department of Preventive Medicine and Public Health, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan

Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Katushika-ku, Tokyo, Japan.

出版信息

BMJ Open. 2023 Mar 7;13(3):e065322. doi: 10.1136/bmjopen-2022-065322.

Abstract

OBJECTIVES

To investigate the association between secondhand-aerosol exposure from heated tobacco products (HTPs) and respiratory symptoms among current non-smokers.

DESIGN

Cross-sectional study.

SETTING

Internet survey conducted between 8 and 26 February 2021 in Japan.

PARTICIPANTS

Non-smoking respondents at the survey aged 15-80 years.

EXPOSURE

Self-reported secondhand-aerosol exposure.

PRIMARY AND SECONDARY OUTCOMES

We defined asthma/asthma-like symptoms as a primary outcome and persistent cough as a secondary outcome. We examined the association between secondhand-aerosol exposure from HTPs and respiratory symptoms (asthma attacks/asthma-like symptoms and persistent cough). The prevalence ratio (PR) and 95% CI were calculated by using weighted, multivariable 'modified' Poisson regression models.

RESULTS

Of the 18 839 current non-smokers, 9.8% (95% CI 8.2% to 11.7%) and 16.7% (95% CI 14.8% to 18.9%) of those who were exposed to secondhand aerosols reported asthma attacks/asthma-like symptoms and persistent cough, whereas 4.5% (95% CI 3.9% to 5.2%) and 9.6% (95% CI 8.4% to 11.0%) of those who were not, respectively. Secondhand-aerosol exposure was associated with respiratory symptoms (asthma attacks/asthma-like symptoms: PR 1.49, 95% CI 1.21 to 1.85; persistent cough: PR 1.44, 95% CI 1.21 to 1.72) after adjusting for covariates.

CONCLUSION

Secondhand-aerosol exposure from HTPs was associated with both asthma attacks/asthma-like symptoms and persistent cough. These results provide policymakers with meaningful information in the regulation of HTP use for the protection of current non-smokers.

摘要

目的

研究加热烟草制品(HTP)二手气溶胶暴露与当前非吸烟者呼吸系统症状之间的关系。

设计

横断面研究。

地点

2021 年 2 月 8 日至 26 日在日本进行的互联网调查。

参与者

调查中年龄在 15 至 80 岁的非吸烟应答者。

暴露

自我报告的二手气溶胶暴露。

主要和次要结局

我们将哮喘/哮喘样症状定义为主要结局,将持续性咳嗽定义为次要结局。我们检查了 HTP 二手气溶胶暴露与呼吸系统症状(哮喘发作/哮喘样症状和持续性咳嗽)之间的关系。使用加权、多变量“修正”泊松回归模型计算患病率比(PR)和 95%置信区间。

结果

在 18839 名当前非吸烟者中,暴露于二手气溶胶的人群报告哮喘发作/哮喘样症状和持续性咳嗽的比例分别为 9.8%(95%CI 8.2%至 11.7%)和 16.7%(95%CI 14.8%至 18.9%),而未暴露于二手气溶胶的人群报告哮喘发作/哮喘样症状和持续性咳嗽的比例分别为 4.5%(95%CI 3.9%至 5.2%)和 9.6%(95%CI 8.4%至 11.0%)。调整协变量后,二手气溶胶暴露与呼吸系统症状(哮喘发作/哮喘样症状:PR 1.49,95%CI 1.21 至 1.85;持续性咳嗽:PR 1.44,95%CI 1.21 至 1.72)相关。

结论

HTP 二手气溶胶暴露与哮喘发作/哮喘样症状和持续性咳嗽均相关。这些结果为决策者在 HTP 使用监管方面提供了有意义的信息,以保护当前非吸烟者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8b9/10008163/4faca8be4cea/bmjopen-2022-065322f01.jpg

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