Pechyonkin E V, Kovrizhkin A V, Pekshev A V, Vagapov A B, Sharapov N A, Vanin A F
Stavropol State Medical University, 355017 Stavropol, Russia.
City Clinical Hospital no. 3, 355029 Stavropol, Russia.
Biophysics (Oxf). 2022;67(6):1023-1032. doi: 10.1134/S0006350922060185. Epub 2023 Mar 3.
A method of treatment of a new coronavirus infection COVID-19 in patients undergoing high flow oxygenation is proposed and technically implemented; the method is based on high-dose inhalation of gaseous nitric oxide (NO) with the patient's spontaneous breathing. The results of the treatment of this disease demonstrating the high efficiency of the new method are presented. A possible mechanism of the blocking effect of high doses of inhaled nitric oxide on the replication of the SARS-CoV-2 virus is discussed; it is based on the formation of dinitrosyl iron complexes in the respiratory tract and lungs of COVID-19 patients with thiol-containing ligands acting as donors of NO and nitrosonium NO cations in a living organism that have a cytotoxic effect on the SARS CoV-2 virus.
提出并在技术上实施了一种针对接受高流量氧疗的新型冠状病毒感染COVID-19患者的治疗方法；该方法基于在患者自主呼吸时高剂量吸入气态一氧化氮（NO）。展示了该新方法高效性的这种疾病的治疗结果。讨论了高剂量吸入一氧化氮对SARS-CoV-2病毒复制的阻断作用的可能机制；它基于在COVID-19患者的呼吸道和肺部形成二亚硝基铁配合物，含硫醇配体在活生物体中作为NO供体和亚硝基阳离子NO发挥作用，对SARS-CoV-2病毒具有细胞毒性作用。
