Department of Medical Biochemistry, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Department of Infectious Diseases, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.
Lab Med. 2023 Nov 2;54(6):582-586. doi: 10.1093/labmed/lmad009.
In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment.
We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P < .05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant.
The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant.
Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions.
本研究旨在评估接受黏菌素治疗患者的血清肌酐（SCr）水平与参考变化值（RCV）。
我们回顾性记录了 47 例接受黏菌素治疗患者治疗前及治疗后第 3、7 天的 SCr 水平。RCV 采用不对称 RCV 公式（Z = 1.64，P <.05）计算。将患者的 SCr 结果的百分比（%）增加与 RCV 进行比较，超过 RCV 的数值被认为具有统计学意义。
SCr 的 RCV 计算为 15.6%。与治疗前值相比，第 3 天的 SCr 值为 32/47，第 7 天的 SCr 值为 36/47；由于这些结果超过了 RCV，因此被认为具有统计学意义。
在连续测量结果的解释中使用 RCV 将提供更快速和敏感的决策方法。
