Stafanger G
Dept. of Pediatrics, Rigshopitalet, Copenhagen, Denmark.
Allergy. 1987 Oct;42(7):507-11. doi: 10.1111/j.1398-9995.1987.tb00373.x.
Human nasal cilia were perfused with aqueous solutions of two corticosteroid aerosols, beclomethasone dipropionate (BPD) and flunisolide, with the main preservative of flunisolide, propylene glycol, and with placebo. The concentration used were BPD 0.1 mg/ml, 0.05 mg/ml, 0.005 mg/ml and 0.0005 mg/ml, flunisolide 0.25 mg/ml, 0.05 mg/ml, 0.025 mg/ml and 0.00025 mg/ml, and propylene glycol 20 mg/ml and 200 mg/ml. A dose-related decrease in ciliary beating frequency (CBF) was seen after perfusion with both BDP and flunisolide as well as propylene glycol. The decrease in CBF following perfusion with propylene glycol was partially reversible upon re-perfusion with medium alone, whereas the decrease seen after BDP and flunisolide was irreversible. Although previous studies have shown no adverse effect on the mucous membrane except for the areas hit by the impact of the sprays, our results suggest that caution should be taken when the dose and/or the length of treatment is considered, and that the effect of administration of these drugs on CBF in vivo needs to be investigated.
用人鼻纤毛灌注两种皮质类固醇气雾剂的水溶液，即二丙酸倍氯米松（BPD）和氟尼缩松，以及氟尼缩松的主要防腐剂丙二醇和安慰剂。使用的浓度分别为：BPD 0.1毫克/毫升、0.05毫克/毫升、0.005毫克/毫升和0.0005毫克/毫升；氟尼缩松0.25毫克/毫升、0.05毫克/毫升、0.025毫克/毫升和0.00025毫克/毫升；丙二醇20毫克/毫升和200毫克/毫升。用BPD、氟尼缩松以及丙二醇灌注后，均观察到纤毛摆动频率（CBF）呈剂量相关下降。用丙二醇灌注后CBF的下降在用单纯培养基重新灌注时部分可逆，而BPD和氟尼缩松灌注后所见的下降是不可逆的。尽管先前的研究表明，除喷雾冲击部位外，对黏膜无不良影响，但我们的结果表明，在考虑剂量和/或治疗时长时应谨慎，且这些药物在体内给药对CBF的影响有待研究。
