Department of Agricultural Biotechnology, Agriculture Faculty, Erciyes University, Erciyes Technopark, Nutral Therapy Co., Kayseri, Turkey.
Department of Histology and Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkey.
Z Geburtshilfe Neonatol. 2023 Aug;227(4):261-268. doi: 10.1055/a-2010-4009. Epub 2023 Mar 8.
Propolis has become one of the most preferred supplements due to its beneficial biological properties. Organic (water and vegetable oils) and chemical (ethyl alcohol, propylene glycol, and glycerol) solvents are used for propolis extraction. However, the effects of these chemicals on health should be taken into account.
In this study, the effects of propolis extracts on health were evaluated.
32 pregnant Wistar albino rats and 64 neonatal/young adults were given three different extractions of propolis (propylene glycol, water, and olive oil). Histopathological analyses were performed on the liver and brain, and blood samples were taken from the hearts of rats.
Histopathological scoring showed that the intensity of pycnotic hepatocyte, sinusoidal dilatation, and bleeding was high in liver samples of pregnant and baby rats given propylene glycol extract of propolis (p<0.05). Propylene glycol extract caused dilatation of blood vessels and apoptosis of neurons in brain tissue. The histopathological score was significantly lower in liver and brain tissues of rats treated with water and olive oil extract compared to propylene propolis groups (p<0.05). Liver enzyme levels in the blood increased in propylene propolis rats (p<0.05).
Histopathological changes and biochemical alterations may indicate that propylene glycol extracts of propolis are more toxic than olive oil and water extracts. Therefore, olive oil and water extracts of propolis are more reliable than propylene glycol extract in pregnant and infant rats.
由于具有有益的生物学特性，蜂胶已成为最受欢迎的补品之一。蜂胶的提取可使用有机溶剂（水和植物油）和化学溶剂（乙醇、丙二醇和甘油）。然而，应考虑这些化学物质对健康的影响。
本研究评估了蜂胶提取物对健康的影响。
32 只怀孕 Wistar 白化大鼠和 64 只新生/幼鼠分别给予三种不同的蜂胶提取物（丙二醇、水和橄榄油）。对肝脏和大脑进行组织病理学分析，并从大鼠心脏采集血液样本。
组织病理学评分显示，给予蜂胶丙二醇提取物的怀孕和幼鼠的肝组织中，固缩肝细胞、窦状扩张和出血的强度较高（p<0.05）。丙二醇提取物导致血管扩张和脑组织中神经元凋亡。与丙二醇蜂胶组相比，水和橄榄油提取物处理的大鼠的肝和脑组织的组织病理学评分明显较低（p<0.05）。丙二醇蜂胶大鼠的血液中肝酶水平升高（p<0.05）。
组织病理学变化和生化改变可能表明蜂胶的丙二醇提取物比橄榄油和水提取物的毒性更大。因此，橄榄油和水提取物在怀孕和婴儿大鼠中比丙二醇提取物更可靠。
