Silici Sibel, Demiray Sevim, Okan Aslı, Ertuğrul Sena, Alizada Sahar, Doğanyiğit Züleyha
Department of Agricultural Biotechnology, Faculty of Agriculture, Nutral Therapy Erciyes University Kayseri Turkey.
Department of Histology and Embryology, Faculty of Medicine Yozgat Bozok University Yozgat Turkey.
Food Sci Nutr. 2024 May 13;12(8):5538-5547. doi: 10.1002/fsn3.4199. eCollection 2024 Aug.
Propolis is widely used as a supplementary food product for its health benefits. The aim of this study was to determine the effects of commercial propolis extracts on the liver and kidney. Propolis extracts (250 mg/kgbw/day) were administered orally to adult male rats in solvents of ethanol, propylene glycol, water, and olive oil. Liver enzyme levels were determined biochemically in blood samples, and histopathological examinations were performed on the liver. Damage rate in both kidney tissue in the propolis-ethanol extract group increased significantly compared with the other groups after 30 and 90 days of application ( < .05). According to the results, ethanol, used as a common solvent in propolis products, may adversely affect the liver in long-term use. The data indicate that propolis-olive oil extract may be an essential alternative due to its effective and reliable properties.
蜂胶因其对健康有益而被广泛用作补充食品。本研究的目的是确定市售蜂胶提取物对肝脏和肾脏的影响。将蜂胶提取物（250毫克/千克体重/天）以乙醇、丙二醇、水和橄榄油为溶剂口服给予成年雄性大鼠。通过生化方法测定血样中的肝酶水平，并对肝脏进行组织病理学检查。在应用30天和90天后，蜂胶-乙醇提取物组的肾脏组织损伤率与其他组相比均显著增加（P＜0.05）。根据结果，作为蜂胶产品常用溶剂的乙醇在长期使用时可能会对肝脏产生不利影响。数据表明，蜂胶-橄榄油提取物因其有效且可靠的特性可能是一种重要的替代品。
