新冠病毒 mRNA 疫苗接种后出现 IgG4 相关疾病。
IgG4-related Disease Emerging after COVID-19 mRNA Vaccination.
机构信息
Department of Rheumatology and Allergy, IMSUT Hospital, the Institute of Medical Science, the University of Tokyo, Japan.
出版信息
Intern Med. 2023 May 15;62(10):1547-1551. doi: 10.2169/internalmedicine.1125-22. Epub 2023 Mar 8.
A 78-year-old Japanese woman with no history of rheumatic disease received 2 doses of the BNT162b2 COVID-19 mRNA vaccine. Two weeks later, she noticed bilateral swelling in the submandibular region. Blood tests showed hyper-immunoglobulin (Ig)G4emia, and F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) revealed the strong accumulation of FDG in the enlarged pancreas. She was diagnosed with IgG4-related disease (IgG4-RD) according to the American College of Rheumatology (ACR)/the European League Against Rheumatism (EULAR) classification criteria. Treatment was started with prednisolone at 30 mg/day, and the organ enlargement improved. We herein report a case of IgG4-RD that may have been associated with an mRNA vaccine.
一位 78 岁的日本女性，既往无风湿病史，接种了两剂 BNT162b2 COVID-19 mRNA 疫苗。两周后，她注意到双侧下颌下区域肿胀。血液检查显示高免疫球蛋白（Ig）G4 血症，氟-18 脱氧葡萄糖（FDG）正电子发射断层扫描（PET）显示 FDG 在肿大的胰腺中强烈积聚。根据美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）分类标准，她被诊断为 IgG4 相关疾病（IgG4-RD）。开始用泼尼松龙 30 mg/天治疗，器官肿大得到改善。我们在此报告一例可能与 mRNA 疫苗相关的 IgG4-RD 病例。
Zotero 插件