State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Angew Chem Int Ed Engl. 2023 Jun 12;62(24):e202218768. doi: 10.1002/anie.202218768. Epub 2023 Apr 3.
Conventional photocages only respond to short wavelength light, which is a significant obstacle to developing efficient phototherapy in vivo. The development of photocages activated by near-infrared (NIR) light at wavelengths from 700 to 950 nm is important for in vivo studies but remains challenging. Herein, we describe the synthesis of a photocage based on a ruthenium (Ru) complex with NIR light-triggered photocleavage reaction. The commercial anticancer drug, tetrahydrocurcumin (THC), was coordinated to the Ru center to create the Ru-based photocage that is readily responsive to NIR light at 760 nm. The photocage inherited the anticancer properties of THC. As a proof-of-concept, we further engineered a self-assembled photocage-based nanoparticle system with amphiphilic block copolymers. Upon exposure to NIR light at 760 nm, the Ru complex-based photocages were released from the polymeric nanoparticles and efficiently inhibited tumor proliferation in vivo.
传统光笼仅对短波长光响应，这是开发体内高效光疗的重大障碍。开发波长在 700 至 950nm 近红外（NIR）光激活的光笼对于体内研究很重要，但仍然具有挑战性。本文描述了一种基于钌（Ru）配合物的光笼的合成，该光笼具有 NIR 光触发的光解反应。将市售抗癌药物四氢姜黄素（THC）与 Ru 中心配位，形成对 760nmNIR 光有良好响应的 Ru 基光笼。该光笼继承了 THC 的抗癌特性。作为概念验证，我们进一步用两亲性嵌段共聚物设计了一种自组装的基于光笼的纳米颗粒系统。在暴露于 760nmNIR 光时，基于 Ru 配合物的光笼从聚合物纳米颗粒中释放出来，并有效地抑制了体内肿瘤的增殖。
