Handegård Karin Westereng, Storengen Linn Mari, Joergensen Dina, Lingaas Frode
Department of Preclinical Sciences and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, P.O. Box 5003, 1432, Ås, Norway.
Canine Med Genet. 2023 Mar 8;10(1):2. doi: 10.1186/s40575-023-00125-0.
Fear of firework noises and other loud, sudden noises (noise reactivity) is a significant problem for many dogs and may have a negative effect on both welfare and, in severe cases, the life expectancy of dogs. A wide range of behavior traits, including fear-related behaviors, have high heritability estimates in dogs. The aim of this study was to estimate genomic heritability for fear of fireworks and loud noises in dogs.
A genomic heritability estimate was performed based on genome-wide SNPs from standard poodles with records of fear of fireworks and noise reactivity. The study was based on questionnaires answered by owners, who also volunteered to return a cheek swab from their dog for DNA analyses. SNP-based heritability was estimated to be 0.28 for firework fear and 0.16 for noise reactivity. We also identified an interesting region on chromosome 17 that was weakly associated with both traits.
We have estimated low to medium genomic heritabilities for fear of fireworks and noise reactivity in standard poodles. We have also identified an interesting region on chromosome 17, which harbors genes that have been shown to be involved in different psychiatric traits with anxiety components in humans. The region was associated with both traits; however, the association was weak and need further verification from other studies.
对烟花噪音及其他响亮、突然的噪音产生恐惧（噪音反应性）对许多犬类来说是一个重大问题，可能会对犬类的福利产生负面影响，在严重情况下还会影响其预期寿命。包括恐惧相关行为在内的多种行为特征在犬类中具有较高的遗传力估计值。本研究的目的是估计犬类对烟花和响亮噪音恐惧的基因组遗传力。
基于有烟花恐惧和噪音反应性记录的标准贵宾犬的全基因组单核苷酸多态性（SNP）进行了基因组遗传力估计。该研究基于犬主回答的问卷，犬主还自愿提供其犬只的颊拭子用于DNA分析。基于SNP的遗传力估计，烟花恐惧为0.28，噪音反应性为0.16。我们还在17号染色体上确定了一个有趣的区域，该区域与这两种特征均存在弱关联。
我们估计了标准贵宾犬对烟花恐惧和噪音反应性的低至中等基因组遗传力。我们还在17号染色体上确定了一个有趣的区域，该区域包含的基因已被证明与人类具有焦虑成分的不同精神特征有关。该区域与这两种特征均有关联；然而，这种关联较弱，需要其他研究进一步验证。
