North China University of Science and Technology, 063000 Tangshan, Hebei, China.
NDepartment of stomatology, HeBei General Hospital, 050000 Shijiazhuang, Hebei, China.
J Clin Pediatr Dent. 2023 Mar;47(2):85-100. doi: 10.22514/jocpd.2023.014. Epub 2023 Mar 3.
This paper systematically evaluate the effects of probiotics on preventing caries in preschool children. The present systematic review was conducted following the Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines and recorded in the International prospective register of systematic reviews (PROSPERO) database (registration no: CRD42022325286). Literature were screened from PubMed, Embase, Web of Sciences, China National Knowledge Infrastructure (CNKI), Wanfang and other databases from inception to April 2022 to identify randomized controlled trials on the clinical efficacies of probiotics in preventing dental caries in preschool children and extract relevant data. The meta-analysis was performed using the RevMan5.4 software and the Stata16. Cochrane handbook was used to assess the risk of bias. The Grading of Recommendations Assessment, Development and Evaluation (GRADEprofiler 3.6) was used to determine the evidence quality. A total of 17 randomized controlled trials were eligible, of which two trials had certain levels of bias and 15 had a low risk of bias. Evidence quality assessment showed that the included trials were of medium quality. The meta-analysis results showed that was associated with a reduced incidence ( = 0.005) and progression ( < 0.001) of caries in preschool children. Probiotics could reduce the number of high-level Streptococcus mutans in saliva ( 0.00001) but could not reduce the number of Streptococcus mutans in dental plaque nor the amount of Lactobacillus in the saliva and dental plaque. Current evidence shows that probiotics could prevent caries in preschool children, but was more effective in preventing caries than others. Although probiotics could reduce high levels of Streptococcus mutans in saliva, they could not reduce the amount of Lactobacillus in saliva and dental plaque.
本文系统评估了益生菌预防学龄前儿童龋齿的效果。本系统评价遵循透明报告系统评价和荟萃分析（PRISMA）指南，并在国际前瞻性系统评价注册库（PROSPERO）数据库中进行了记录（注册号：CRD42022325286）。从 PubMed、Embase、Web of Sciences、中国知网（CNKI）、万方等数据库中检索了从成立到 2022 年 4 月的关于益生菌预防学龄前儿童龋齿的临床疗效的随机对照试验，并提取相关数据。使用 RevMan5.4 软件和 Stata16 进行荟萃分析。使用 Cochrane 手册评估偏倚风险。使用 Grading of Recommendations Assessment, Development and Evaluation（GRADEprofiler 3.6）评估证据质量。共有 17 项随机对照试验符合条件，其中 2 项试验存在一定程度的偏倚，15 项试验的偏倚风险较低。证据质量评估显示，纳入的试验为中等质量。荟萃分析结果表明，益生菌可降低学龄前儿童龋齿的发生率（ = 0.005）和进展率（ < 0.001）。益生菌可降低唾液中高水平变形链球菌的数量（ < 0.00001），但不能降低牙菌斑中变形链球菌的数量，也不能降低唾液和牙菌斑中乳杆菌的数量。目前的证据表明，益生菌可以预防学龄前儿童的龋齿，但与其他益生菌相比， 更能有效预防龋齿。虽然益生菌可以降低唾液中高水平的变形链球菌，但不能降低唾液和牙菌斑中乳杆菌的数量。
