Sufianov Albert, Beilerli Aferin, Kudriashov Valentin, Ilyasova Tatiana, Liang Yanchao, Mukhamedzyanov Albert, Bessonova Marina, Mashkin Andrey, Beylerli Ozal
Educational and Scientific Institute of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Noncoding RNA Res. 2023 Mar 2;8(2):255-262. doi: 10.1016/j.ncrna.2023.02.009. eCollection 2023 Jun.
In recent times, the rising prevalence of obesity and its associated comorbidities have had a severe impact on human health and social progress. Therefore, scientists are delving deeper into the pathogenesis of obesity, exploring the role of non-coding RNAs. Long non-coding RNAs (lncRNAs), once regarded as mere "noise" during genome transcription, have now been confirmed through numerous studies to regulate gene expression and contribute to the occurrence and progression of several human diseases. LncRNAs can interact with protein, DNA, and RNA, respectively, and participate in regulating gene expression by modulating the levels of visible modification, transcription, post-transcription, and biological environment. Increasingly, researchers have established the involvement of lncRNAs in regulating adipogenesis, development, and energy metabolism of adipose tissue (white and brown fat). In this article, we present a literature review of the role of lncRNAs in the development of adipose cells.
近年来，肥胖及其相关合并症的患病率不断上升，对人类健康和社会发展产生了严重影响。因此，科学家们正在更深入地研究肥胖的发病机制，探索非编码RNA的作用。长链非编码RNA（lncRNAs）曾被视为基因组转录过程中的单纯“噪音”，但现在大量研究已证实其可调节基因表达，并在多种人类疾病的发生和发展中发挥作用。LncRNAs可分别与蛋白质、DNA和RNA相互作用，并通过调节表观修饰、转录、转录后及生物学环境水平来参与调控基因表达。越来越多的研究人员已证实lncRNAs参与调节脂肪生成、脂肪组织（白色和棕色脂肪）的发育及能量代谢。在本文中，我们对lncRNAs在脂肪细胞发育中的作用进行了文献综述。
