初诊时高度进展的结直肠癌在埃塞俄比亚患者中的表现：影像学特征及相关因素。

High Magnitude Advanced Colorectal Cancer at Diagnosis in Ethiopian Patients: Imaging Pattern and Associated Factors.

机构信息

Department of radiology, School of Medicine, College of Health Sciences, Addis Ababa University.

出版信息

Ethiop J Health Sci. 2023 Jan;33(1):81-90. doi: 10.4314/ejhs.v33i1.11.

DOI:10.4314/ejhs.v33i1.11

PMID:36890929

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9987274/

Abstract

BACKGROUND

Colorectal cancer (CRC) is one of the most prevalent and incident cancers worldwide with an Increasing prevalence in a younger age in developing countries. The aim of the study was to determine the staging and imaging pattern of CRC at diagnosis.

METHODS

This is a descriptive cross-sectional study including all consecutive cases of CRC found in the departments of radiology and oncology during the study period from March 2016 - February 2017.

RESULTS

A total of 132 CRC cases were studied with M: F = 2.4:1, mean age of 46yrs and 67.4% </= 50yrs. Left-sided tumors were associated with rectal bleeding (p = 0.001) and bowel habit change (p =0.045) whereas right-side tumors were associated with weight loss (p = 0.02) and abdominal pain (p = 0.004). 84.5% of CRC presented at an advanced stage, and 32% had distant metastasis. Young age was associated with the advanced stage (P=0.006) whereas family history was associated with the lower stage (P=0.008). Distance metastasis was associated with Colonic lesions (P=0.003) and emergent presentation (P=0.008). Asymmetric wall thickening with luminal narrowing was significantly associated with left side tumor (95% vs 21.4%) whereas large mass with necrosis was significantly associated with right side tumor (50% vs 5%) (P= 0.004).

CONCLUSIONS

CRC is presented at a younger age and at an advanced stage. The majority of CRCs were left-sided and rectal. Increasing the index of suspicion for CRC in patients with rectal bleeding and, bowel habit change is recommended.

摘要

背景

结直肠癌（CRC）是全球最常见和最常发生的癌症之一，在发展中国家，其发病率呈年轻化趋势。本研究旨在确定CRC 的分期和诊断时的影像学表现。

方法

这是一项描述性的横断面研究，包括 2016 年 3 月至 2017 年 2 月期间放射科和肿瘤科连续发现的所有 CRC 病例。

结果

共研究了 132 例 CRC 病例，男女比例为 2.4:1，平均年龄为 46 岁，67.4% </= 50 岁。左侧肿瘤与直肠出血（p = 0.001）和排便习惯改变（p = 0.045）相关，而右侧肿瘤与体重减轻（p = 0.02）和腹痛（p = 0.004）相关。84.5%的 CRC 处于晚期，32%有远处转移。年轻与晚期相关（P=0.006），而家族史与较低的分期相关（P=0.008）。远处转移与结肠病变（P=0.003）和紧急就诊（P=0.008）相关。不对称性壁增厚伴管腔狭窄与左侧肿瘤显著相关（95% vs 21.4%），而伴有坏死的大肿块与右侧肿瘤显著相关（50% vs 5%）（P=0.004）。