Nowak C, Arnold W, Henneberger G, Naundorf H, Kunde D
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Arch Geschwulstforsch. 1987;57(5):361-72.
We have examined the possibility of transplanting syngeneic and xenogeneic tumor material below the renal capsule of normal, immunocompetent mice as a chemotherapeutic test model. Whereas the Lewis lung carcinoma in the syngeneic system was appropriated for the 6-day-test, only 56% of spontaneous C3H mammary carcinomas showed an increase in the size of the transplanted material. An individual sensitivity to the cytostatic agents as an expression of biological variability could be detected for primary C3H mammary carcinomas. Both, xenogeneic lines of human origin, established in nude mice, and fresh resection material from the clinic showed on the normal, immunocompetent mouse no time-dependent, reproducible growth of the transplanted material in control animals. However, growth is considered as a precondition for estimating the effect of therapy. The normal, immunocompetent mouse was in our experiments not suitable for application of the renal capsule assay in the 6-day-test as a recipient for xenogeneic transplantation.
我们已研究了将同基因和异种肿瘤材料移植到正常、具有免疫活性的小鼠肾包膜下作为化疗测试模型的可能性。在同基因系统中，Lewis肺癌适用于为期6天的测试，而自发的C3H乳腺癌中只有56%的移植材料大小有所增加。对于原发性C3H乳腺癌，可以检测到个体对细胞抑制剂的敏感性，这是生物变异性的一种表现。在裸鼠中建立的两种人类异种系以及来自临床的新鲜切除材料，在正常、具有免疫活性的小鼠中，对照动物的移植材料均未呈现出随时间变化的、可重复的生长。然而，生长被认为是评估治疗效果的一个前提条件。在我们的实验中，正常、具有免疫活性的小鼠不适合作为异种移植受体用于为期6天的肾包膜试验。
