Szasz G, Stevenson R W, Lee L, Sanders H D
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
Arch Sex Behav. 1987 Oct;16(5):371-8. doi: 10.1007/BF01541420.
Recent data suggest that intracavernous injections of phenoxybenzamine in saline, and/or papaverine with phentolamine mesylate in saline, result in erection in otherwise impotent men. A double-blind study using normal saline and normal saline mixed with phenoxybenzamine or papaverine-phenotolamine mesylate showed that none of 11 subjects with organic erection dysfunction responded with appreciable penile swelling to saline injection, but all responded with some degree of penile swelling to the other solutions. The mechanism of penile erection in response to intracavernous injections is still unclear, but it is thought to be related to the alpha-adrenergic blocking and/or smooth muscle relaxant actions of these drugs; the volume of the injection or the normal saline content of the solution are not factors in causing penile tumescence.
近期数据表明，向海绵体内注射苯苄胺的生理盐水溶液，和/或注射罂粟碱与甲磺酸酚妥拉明的生理盐水溶液，可使原本阳痿的男性勃起。一项使用生理盐水以及混合了苯苄胺或罂粟碱-甲磺酸酚妥拉明的生理盐水进行的双盲研究显示，11名患有器质性勃起功能障碍的受试者中，无人因注射生理盐水而出现明显的阴茎肿胀反应，但所有人对其他溶液均有一定程度的阴茎肿胀反应。海绵体内注射引发阴茎勃起的机制尚不清楚，但据认为与这些药物的α-肾上腺素能阻断作用和/或平滑肌松弛作用有关；注射溶液的体积或其中生理盐水的含量并非导致阴茎肿胀的因素。
