Ariello Leonardo E, de Souza Andrade Thais, Mello Luiz Guilherme Marchesi, Oyamada Maria Kiyoko, Cunha Leonardo Provetti, Monteiro Mário L R
Division of Ophthalmology and the Laboratory of Investigation in Ophthalmology (LIM 33), University of São Paulo Medical School, São Paulo, Brazil.
Department of Specialized Medicine, Centro de Ciências da Saúde (CCS), Universidade Federal do Espírito Santo, Vitoria, Brazil.
Neuroophthalmology. 2022 Sep 7;47(2):88-92. doi: 10.1080/01658107.2022.2107686. eCollection 2023.
Ischaemic optic neuropathy is the most common, feared, and recognised ocular manifestation of giant cell arteritis (GCA), while extraocular muscle palsy rarely occurs in the disease. Overlooking the diagnosis of GCA in aged patients with acquired diplopia and strabismus is not only sight- but also life-threatening. Here, we present, for the first time, a case of unilateral abducens nerve palsy and contralateral anterior ischaemic optic neuropathy as the presenting signs of GCA in a 98-year-old woman. Prompt diagnosis and treatment prevented further visual loss and systemic complications and allowed for rapid resolution of the abducens nerve palsy. We also aim to discuss the possible pathophysiological mechanisms of diplopia in GCA and to emphasise that acquired cranial nerve palsy must raise suspicion of this severe disease in elderly patients, particularly in association with ischaemic optic neuropathy.
缺血性视神经病变是巨细胞动脉炎(GCA)最常见、最可怕且已被认识到的眼部表现,而眼外肌麻痹在该疾病中很少发生。在患有后天性复视和斜视的老年患者中忽视GCA的诊断不仅会危及视力,还会危及生命。在此,我们首次报告一例98岁女性以单侧展神经麻痹和对侧前部缺血性视神经病变为首发症状的GCA病例。及时诊断和治疗可预防进一步的视力丧失和全身并发症,并使展神经麻痹迅速缓解。我们还旨在探讨GCA中复视可能的病理生理机制,并强调后天性脑神经麻痹必须引起对老年患者这种严重疾病的怀疑,尤其是与缺血性视神经病变相关时。