Adair B M, Kennedy S, McKillop E R, McNulty M S, McFerran J B
Veterinary Research Laboratories, Stormont, Belfast, U.K.
Arch Virol. 1987;97(1-2):49-59. doi: 10.1007/BF01310733.
Eleven bovine, 19 porcine, and 3 ovine picornaviruses were tested for their ability to grow in the presence of the viral inhibitors 2-(alpha-hydroxy-benzyl)- benzimidazole (HBB) and guanidine-HC1 (GHC1). The nature of the lesions produced by inoculation of newborn mice with these viruses was also investigated. Nine bovine viruses were inhibited by both compounds, and produced skeletal myonecrosis in mice, suggesting similarities to the human coxsackie group B viruses and indicating potential pathogenicity for bovine species. One bovine virus (VH7) was inhibited by GHC1 but not by HBB and caused widespread skeletal muscle damage in mice typical of coxsackie group A viruses. Another bovine virus (F266a) was inhibited only by HBB. None of the porcine or ovine viruses showed significant inhibition by either compound nor produced lesions in mice.
对11种牛源、19种猪源和3种羊源小RNA病毒进行了测试，以考察它们在病毒抑制剂2 -（α-羟基苄基）-苯并咪唑（HBB）和盐酸胍（GHC1）存在的情况下的生长能力。还研究了用这些病毒接种新生小鼠所产生病变的性质。9种牛源病毒被这两种化合物抑制，并在小鼠中引起骨骼肌坏死，这表明它们与人类柯萨奇B组病毒相似，并提示对牛具有潜在致病性。一种牛源病毒（VH7）被GHC1抑制，但不被HBB抑制，并在小鼠中引起典型的柯萨奇A组病毒所致的广泛骨骼肌损伤。另一种牛源病毒（F266a）仅被HBB抑制。猪源和羊源病毒均未显示出被任何一种化合物显著抑制，也未在小鼠中产生病变。
