Garland J M, Mann J A
J Hyg (Lond). 1974 Aug;73(1):85-96. doi: 10.1017/s0022172400023871.
Despite the existence of a close serological relationship between the enteroviruses Swine Vesicular Disease (SVD) and Coxsackie type B5 (Cx B5), the administration of this Coxsackie virus type to susceptible pigs by various routes failed to produce clinical disease.Viraemia was not detected after exposure but virus was recovered intermittently from faeces and buccal swabs. A mixed virus population was demonstrated in faecal cultures from some pigs, including Coxsackie virus type B5 and other agents, presumably native pig enteroviruses. The Coxsackie virus persisted in faeces in declining amounts for up to 8 days after primary exposure.Serum neutralizing antibody showed a transient rise to Coxsackie virus, reaching a peak at 14 days and declining below demonstrable titres by 28 days after exposure. The antibody titres attained were proportional to the dose of virus administered and the degree of neutralization was very similar to both SVD and Cx B5 viruses.On cross challenge by exposure to SVD virus 28 days after exposure to Cx B5 virus, most animals (5/6) succumbed with typical vesicular lesions, although the serum neutralizing antibody titres showed a characteristically anamnestic response to both viruses.
尽管肠道病毒猪水疱病（SVD）与B5型柯萨奇病毒（Cx B5）之间存在密切的血清学关系，但通过各种途径将这种B5型柯萨奇病毒接种到易感猪体内均未引发临床疾病。接触病毒后未检测到病毒血症，但从粪便和口腔拭子中间歇性地分离到病毒。在一些猪的粪便培养物中发现了混合病毒群体，包括B5型柯萨奇病毒和其他病原体，推测是猪源肠道病毒。初次接触后，柯萨奇病毒在粪便中持续存在，数量逐渐减少，长达8天。血清中和抗体对柯萨奇病毒呈短暂升高，在接触后14天达到峰值，到28天时降至可检测水平以下。所达到的抗体滴度与接种的病毒剂量成正比，中和程度与SVD病毒和Cx B5病毒非常相似。在接触Cx B5病毒28天后再接触SVD病毒进行交叉攻击时，大多数动物（5/6）出现典型的水疱性病变而死亡，尽管血清中和抗体滴度对两种病毒均表现出典型的回忆反应。
