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[肝窦阻塞综合征的研究进展]

[Research progress of hepatic sinusoidal obstruction syndrome].

作者信息

Ke Z L, Liu Y L

机构信息

Department of Gastroenterology, Peking University People's Hospital, Beijing 100044.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2022 Dec 20;30(12):1298-1303. doi: 10.3760/cma.j.cn501113-20221110-00556.

Abstract

Hepatic sinusoidal obstruction syndrome (HSOS) is a hepatic vascular disease that begins with injury to hepatic sinusoidal endothelial cells, and has a fatality rate of over 80% in its severe form. Therefore, early diagnosis and treatment are crucial to delay HSOS progression and reduce mortality. However, clinicians' understanding of the disease is still insufficient, and the clinical manifestations of the disease are similar to liver diseases caused by other etiologies, resulting in a high rate of misdiagnosis. This article mainly introduces the HSOS recent developments in the etiology and pathogenesis, clinical manifestations and auxiliary examinations, diagnostic criteria, treatment, and prevention.

摘要

肝窦阻塞综合征(HSOS)是一种肝脏血管疾病,始于肝窦内皮细胞损伤,严重形式的病死率超过80%。因此,早期诊断和治疗对于延缓HSOS进展和降低死亡率至关重要。然而,临床医生对该疾病的认识仍然不足,且该疾病的临床表现与其他病因引起的肝病相似,导致误诊率较高。本文主要介绍HSOS在病因与发病机制、临床表现与辅助检查、诊断标准、治疗及预防方面的最新进展。

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