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[肝窦阻塞综合征诊断标准综述]

[Review on diagnostic criteria of hepatic sinusoidal obstruction syndrome].

作者信息

Liu L, Zhang W, Zhuge Y Z

机构信息

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China; Department of Gastroenterology, Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

出版信息

Zhonghua Gan Zang Bing Za Zhi. 2020 Dec 20;28(12):1064-1068. doi: 10.3760/cma.j.cn501113-20190415-00124.

Abstract

Hepatic sinusoidal obstruction syndrome (HSOS) is a kind of hepatic vascular disease which is characterized by damage to hepatic sinusoidal endothelial cells, centrilobular hepatic vein and/or interlobular vein, resulting in stenosis or lumen occlusion, hepatic injury and acute sinusoidal portal hypertension. Generally, most patients with HSOS have mild manifestations, but in severely ill patients, the disease can lead to multiple organ dysfunction/failure, and the mortality rate can be as high as 70%-80%. Therefore, it is important to identify and treat HSOS as soon as possible. This paper introduces the current clinical diagnostic criteria of HSOS, including the Modified Seattle and Baltimore Criteria along with "Nanjing Criteria", and reviews their characteristics, scope of application and limitations.

摘要

肝窦阻塞综合征(HSOS)是一种肝血管疾病,其特征是肝窦内皮细胞、小叶中央肝静脉和/或小叶间静脉受损,导致狭窄或管腔闭塞、肝损伤和急性窦性门静脉高压。一般来说,大多数HSOS患者表现较轻,但在重症患者中,该病可导致多器官功能障碍/衰竭,死亡率可达70%-80%。因此,尽早识别和治疗HSOS很重要。本文介绍了HSOS目前的临床诊断标准,包括改良西雅图和巴尔的摩标准以及“南京标准”,并对其特点、适用范围和局限性进行了综述。

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