Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Department of Urology, Peking University First Hospital, Beijing 100000, China.
Asian J Androl. 2023 Sep 1;25(5):637-642. doi: 10.4103/aja2022121. Epub 2023 Mar 3.
Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and behaviors. The aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors, as well as to make a preliminary assessment of aerobic exercise as a complementary strategy to dapoxetine treatment in rapid ejaculators. Copulatory tests of rats and a treadmill training protocol were performed in this study. In total, 12 rapid ejaculators were selected on the basis of ejaculation distribution theory and randomly assigned to 4 groups: control (Ctrol) group, aerobic exercise (Ex) group, dapoxetine (Dapo) group, and Ex+Dapo group. We evaluated the changes in ejaculatory parameters in the 4 groups. Variations in biological markers, including serum corticosterone, serotonin (5-HT), and brain-derived neurotrophic factor (BDNF) of the raphe nucleus, were determined by enzyme-linked immunosorbent assay (ELISA). The primary finding of our study was that both aerobic exercise and acute dapoxetine could enhance ejaculation control and prolong ejaculation latency in rapid ejaculator rats. The ejaculation delay effect of aerobic exercise was nearly equivalent to that of acute dapoxetine. In addition, both aerobic exercise and dapoxetine treatment could lead to increased expression of BDNF and 5-HT in the raphe nucleus of rapid ejaculators. Moreover, the two interventions, when applied together, may further upregulate the expression of BDNF-5-HT duo in a complementary manner. This study highlights the positive effects of aerobic exercise on ejaculation control. Regular aerobic exercise might be a promising complementary treatment to dapoxetine in rats.
越来越多的证据表明，有规律的有氧运动有益于大脑健康和行为。本研究旨在探讨有氧运动对射精行为的影响，并初步评估有氧运动作为快速射精者达泊西汀治疗的补充策略的效果。本研究进行了大鼠交配测试和跑步机训练方案。根据射精分布理论，总共选择了 12 名快速射精者，并随机分为 4 组：对照组（Ctrol）、有氧运动组（Ex）、达泊西汀组（Dapo）和 Ex+Dapo 组。我们评估了 4 组射精参数的变化。通过酶联免疫吸附试验（ELISA）测定血清皮质酮、血清素（5-HT）和中缝核脑源性神经营养因子（BDNF）等生物标志物的变化。我们的主要发现是，有氧运动和急性达泊西汀都可以增强快速射精大鼠的射精控制并延长射精潜伏期。有氧运动的射精延迟效果几乎与急性达泊西汀相当。此外，有氧运动和达泊西汀治疗都可以导致快速射精者中缝核 BDNF 和 5-HT 的表达增加。而且，当两种干预措施一起应用时，可能会以互补的方式进一步上调 BDNF-5-HT 双表达。这项研究强调了有氧运动对射精控制的积极影响。有规律的有氧运动可能是达泊西汀治疗快速射精者的一种很有前途的补充治疗方法。
