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Right Ventricular Dysfunction in Pulmonary Hypertension: Is Resistin a Promising Target?

作者信息

Lemay Sarah-Eve, Grobs Yann, Boucherat Olivier

机构信息

Pulmonary Hypertension Research Group Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec Québec City Québec Canada.

Department of Medicine Université Laval Québec City Québec Canada.

出版信息

J Am Heart Assoc. 2023 Mar 21;12(6):e8285. doi: 10.1161/JAHA.123.029503. Epub 2023 Mar 9.

DOI:10.1161/JAHA.123.029503
PMID:36892086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10111511/
Abstract
摘要

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Human Resistin Induces Cardiac Dysfunction in Pulmonary Hypertension.人抵抗素导致肺动脉高压性心脏功能障碍。
J Am Heart Assoc. 2023 Mar 21;12(6):e027621. doi: 10.1161/JAHA.122.027621. Epub 2023 Mar 16.
2
PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.PARP1-PKM2轴介导与肺动脉高压相关的右心室衰竭。
JACC Basic Transl Sci. 2022 Mar 16;7(4):384-403. doi: 10.1016/j.jacbts.2022.01.005. eCollection 2022 Apr.
3
The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.肺动脉高压和右心衰竭的最新动物模型。
Circ Res. 2022 Apr 29;130(9):1466-1486. doi: 10.1161/CIRCRESAHA.121.319971. Epub 2022 Apr 28.
4
Hypoxia-Induced Mitogenic Factor: A Multifunctional Protein Involved in Health and Disease.缺氧诱导促有丝分裂因子：一种参与健康与疾病的多功能蛋白质。
Front Cell Dev Biol. 2021 Jul 15;9:691774. doi: 10.3389/fcell.2021.691774. eCollection 2021.
5
Pulmonary artery banding is a relevant model to study the right ventricular remodeling and dysfunction that occurs in pulmonary arterial hypertension.肺动脉环缩术是一种相关的模型，可以研究肺动脉高压中发生的右心室重构和功能障碍。
J Appl Physiol (1985). 2020 Aug 1;129(2):238-246. doi: 10.1152/japplphysiol.00148.2020. Epub 2020 Jul 9.
6
HIMF (Hypoxia-Induced Mitogenic Factor) Signaling Mediates the HMGB1 (High Mobility Group Box 1)-Dependent Endothelial and Smooth Muscle Cell Crosstalk in Pulmonary Hypertension.缺氧诱导有丝分裂因子（HIMF）信号介导 HMGB1（高迁移率族蛋白 1）依赖性肺高血压内皮和平滑肌细胞串扰。
Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2505-2519. doi: 10.1161/ATVBAHA.119.312907. Epub 2019 Oct 10.
7
Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement.研究环境下心功能右心室评估：知识空白与前进道路。美国胸科学会官方研究声明。
Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. doi: 10.1164/rccm.201806-1160ST.
8
Hypoxia-Induced Mitogenic Factor Promotes Cardiac Hypertrophy via Calcium-Dependent and Hypoxia-Inducible Factor-1α Mechanisms.缺氧诱导的有丝分裂因子通过钙依赖性和缺氧诱导因子-1α 机制促进心肌肥大。
Hypertension. 2018 Aug;72(2):331-342. doi: 10.1161/HYPERTENSIONAHA.118.10845. Epub 2018 Jun 11.
9
Here, there and everywhere: Resistin-like molecules in infection, inflammation, and metabolic disorders.无处不在：抵抗素样分子与感染、炎症和代谢紊乱。
Cytokine. 2018 Oct;110:442-451. doi: 10.1016/j.cyto.2018.05.014. Epub 2018 Jun 1.
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The right ventricle in pulmonary arterial hypertension.肺动脉高压中的右心室。
Eur Respir Rev. 2014 Dec;23(134):476-87. doi: 10.1183/09059180.00007414.