Lv Moyang, Liu Wenjuan
Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Department of Pathophysiology, Health Science Center, Shenzhen University, Shenzhen, China.
Front Cell Dev Biol. 2021 Jul 15;9:691774. doi: 10.3389/fcell.2021.691774. eCollection 2021.
Hypoxia-induced mitogenic factor (HIMF), also known as resistin-like molecule α (RELMα) or found in inflammatory zone 1 (FIZZ1) is a member of the RELM protein family expressed in mice. It is involved in a plethora of physiological processes, including mitogenesis, angiogenesis, inflammation, and vasoconstriction. HIMF expression can be stimulated under pathological conditions and this plays a critical role in pulmonary, cardiovascular and metabolic disorders. The present review summarizes the molecular characteristics, and the physiological and pathological roles of HIMF in normal and diseased conditions. The potential clinical significance of these findings for human is also discussed.
缺氧诱导有丝分裂因子（HIMF），也称为抵抗素样分子α（RELMα）或在炎症区域1（FIZZ1）中发现的蛋白，是在小鼠中表达的RELM蛋白家族的成员。它参与众多生理过程，包括有丝分裂、血管生成、炎症和血管收缩。HIMF的表达在病理条件下可被刺激，这在肺部、心血管和代谢紊乱中起关键作用。本综述总结了HIMF在正常和疾病状态下的分子特征、生理和病理作用。还讨论了这些发现对人类的潜在临床意义。
