El-Gendy Kawther S, Osman Khaled A, Ezz El-Din Eslam M, El-Seedy Ayman S
Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University, Alexandria, Egypt.
Department of Genetics, Faculty of Agriculture, Alexandria University, Alexandria, Egypt.
J Environ Sci Health B. 2023;58(3):247-254. doi: 10.1080/03601234.2023.2186682. Epub 2023 Mar 9.
Environmental contamination by complex mixtures of pesticides and metals is a major health problem in agriculture and industry. In real life scenarios, we are exposed to mixtures of chemicals rather than single chemicals, and therefore it is critical to assess their toxicity. The current work was conducted to assess the toxic effects of a low dose (2% median lethal dose) of ethoprophos (Etho, 0.16 mg kg bw), and cadmium (Cd, 0.63 mg kg bw); each alone or in combination on hematological, biochemical, and genotoxic parameters in male mice for one or four weeks. The tested toxicants resulted in a decline in body and organs weights, the most hematological indices, acetylcholine esterase activity, and the total protein content, while they significantly increased liver and kidney function parameters. Furthermore, they increased the mitotic index (MI), number of abnormal sperms, and chromosomes. In conclusion, Etho and Cd induce deleterious effects on all tested parameters in male mice which reflect more obvious impacts when both combined, particularly after 28 days of exposure. However, further research is needed to confirm toxicokinetic or toxicodynamic interactions between these two toxic compounds in the organisms.
农药和金属的复杂混合物对环境的污染是农业和工业中的一个主要健康问题。在现实生活场景中，我们接触的是化学物质的混合物而非单一化学物质，因此评估它们的毒性至关重要。当前的研究旨在评估低剂量（2%半数致死剂量）的丙线磷（Etho，0.16毫克/千克体重）和镉（Cd，0.63毫克/千克体重）单独或联合作用于雄性小鼠1周或4周后对血液学、生化和遗传毒性参数的影响。所测试的毒物导致体重和器官重量下降、大多数血液学指标、乙酰胆碱酯酶活性和总蛋白含量降低，同时显著增加了肝功能和肾功能参数。此外，它们还增加了有丝分裂指数（MI）、异常精子数量和染色体数量。总之，丙线磷和镉对雄性小鼠的所有测试参数均产生有害影响，两者联合时影响更为明显，尤其是在暴露28天后。然而，需要进一步研究来证实这两种有毒化合物在生物体内的毒代动力学或毒效动力学相互作用。
