Breast Center, Theme Cancer, Karolinska University Hospital and Karolinska Comprehensive Cancer Center, Stockholm, Sweden.
Department of Oncology/Pathology, Karolinska Institutet, Stockholm, Sweden.
Mol Oncol. 2023 Apr;17(4):545-547. doi: 10.1002/1878-0261.13413. Epub 2023 Mar 17.
Treatment with immune checkpoint inhibitors (ICI) has revolutionized cancer management for multiple tumor types, including breast cancer. However, not all patients respond to ICI, and unraveling the determinants and mechanisms of response still remains an unmet need. A recent study has uncovered the critical role of eosinophils in mediating immunotherapy effect in breast cancer, mainly by stimulating the activation of CD8+ T-cells. Furthermore, the intratumoral eosinophil recruitment was directed by CD4+ T cells and the interleukins IL-5 and IL-33, thus providing the rationale for targeting eosinophils to enhance ICI response.
免疫检查点抑制剂 (ICI) 的治疗已经彻底改变了多种肿瘤类型的癌症治疗,包括乳腺癌。然而,并非所有患者对 ICI 都有反应,因此阐明反应的决定因素和机制仍然是一个未满足的需求。最近的一项研究揭示了嗜酸性粒细胞在介导乳腺癌免疫治疗效果中的关键作用,主要是通过刺激 CD8+ T 细胞的激活。此外,嗜酸性粒细胞在肿瘤内的募集是由 CD4+ T 细胞和白细胞介素 IL-5 和 IL-33 引导的,这为靶向嗜酸性粒细胞以增强 ICI 反应提供了依据。