Gastroenterology and Endoscopy Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy.
Immunology and Functional Genomics Unit, Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.
Cells. 2023 May 26;12(11):1481. doi: 10.3390/cells12111481.
Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral infection. IL-33 is a novel contributing factor in tumorigenesis and plays a critical role in regulating angiogenesis and cancer progression in a variety of human cancers. The partially unraveled role of IL-33/ST2 signaling in gastrointestinal tract cancers is being investigated through the analysis of patients' samples and by studies in murine and rat models. In this review, we discuss the basic biology and mechanisms of release of the IL-33 protein and its involvement in gastrointestinal cancer onset and progression.
越来越多的证据表明，白细胞介素-33（IL-33）作为白细胞介素-1 家族的一员，在组织动态平衡和修复、2 型免疫、炎症和病毒感染中发挥着关键作用。IL-33 是肿瘤发生的一个新的促成因素，在多种人类癌症中，它在调节血管生成和癌症进展方面起着关键作用。通过对患者样本的分析和对鼠类和大鼠模型的研究，正在研究 IL-33/ST2 信号在胃肠道癌中的部分作用机制。在这篇综述中，我们讨论了 IL-33 蛋白的基本生物学和释放机制，以及它在胃肠道癌发生和进展中的作用。
