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Prospekta 在大鼠局灶性脑缺血模型中盲法安慰剂对照研究中的促智作用。

Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats.

机构信息

Research Institute of General Pathology and Pathophysiology, Moscow, Russia.

LLC "MATERIA MEDICA HOLDING", Moscow, Russia.

出版信息

Bull Exp Biol Med. 2023 Feb;174(4):435-439. doi: 10.1007/s10517-023-05724-2.

Abstract

Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate cognitive disorders in the early recovery period after ischemic stroke). Studies of the nootropic activity in other pathologies of the nervous system are also promising.

摘要

对原药 Prospekta 在局灶性脑缺血大鼠模型中的药理活性分析表明,其具有促智作用:在缺血后时期进行疗程治疗可使动物在神经功能缺损高峰期的神经状态得到恢复。评价药物在形态和功能中枢神经系统紊乱中的治疗潜力使我们能够得出结论,在临床前阶段进一步研究其生物活性是明智的(在动物中获得的结果在临床试验中成功地证实了药物在治疗缺血性中风后早期恢复期中度认知障碍方面的疗效)。在神经系统的其他疾病中研究促智活性也具有广阔的前景。

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