Attella M J, Nattinville A, Stein D G
Clark University Brain Research Laboratory, Worcester, Massachusetts 01610.
Behav Neural Biol. 1987 Nov;48(3):352-67. doi: 10.1016/s0163-1047(87)90918-6.
Pseudopregnant and normal cycling female Sprague-Dawley rats were trained on a delayed-spatial alternation task. After acquisition training, the subjects received frontal cortex lesions and were subsequently tested for retention. The pseudopregnant animals with lesions were less impaired than their normal cycling counterparts. Learning and retention testing were not affected by hormonal status in the noninjured controls. Histological examination showed that the normal cycling rats with frontal cortex lesions possessed enlarged ventricles, indicating the presence of edema in this surgical group. However, brain tissue of pseudopregnant subjects given the same lesion and sham operates of both hormonal states did not display this characteristic of edema. We speculate that the behavioral and anatomical impairment observed in the normal cycling females with brain injury is due to higher levels of vasopressin, a potent vasoconstrictor synchronized with brain injury in our manipulation.
对假孕和正常发情周期的雌性斯普拉格-道利大鼠进行延迟空间交替任务训练。在习得性训练后，对实验对象进行额叶皮质损伤，随后进行记忆保持测试。损伤的假孕动物比正常发情周期的同类动物受损程度小。在未受伤的对照组中，学习和记忆保持测试不受激素状态的影响。组织学检查显示，额叶皮质损伤的正常发情周期大鼠脑室扩大，表明该手术组存在水肿。然而，处于两种激素状态下接受相同损伤和假手术的假孕实验对象的脑组织并未表现出这种水肿特征。我们推测，在脑损伤的正常发情周期雌性动物中观察到的行为和解剖学损伤是由于加压素水平较高，加压素是一种强效血管收缩剂，在我们的操作中与脑损伤同步。
