Pfeiffer Rebecca L, Jones Bryan W
Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, UT, United States.
Front Neuroanat. 2022 Dec 22;16:1099348. doi: 10.3389/fnana.2022.1099348. eCollection 2022.
The retinal degenerative diseases retinitis pigmentosa and age-related macular degeneration are a leading cause of irreversible vision loss. Both present with progressive photoreceptor degeneration that is further complicated by processes of retinal remodeling. In this perspective, we discuss the current state of the field of retinal remodeling and its implications for vision-restoring therapeutics currently in development. Here, we discuss the challenges and pitfalls retinal remodeling poses for each therapeutic strategy under the premise that understanding the features of retinal remodeling in totality will provide a basic framework with which therapeutics can interface. Additionally, we discuss the potential for approaching therapeutics using a combined strategy of using diffusible molecules in tandem with other vision-restoring therapeutics. We end by discussing the potential of the retina and retinal remodeling as a model system for more broadly understanding the progression of neurodegeneration across the central nervous system.
视网膜退行性疾病色素性视网膜炎和年龄相关性黄斑变性是不可逆视力丧失的主要原因。两者均表现为进行性光感受器变性，并因视网膜重塑过程而进一步复杂化。从这个角度出发，我们讨论视网膜重塑领域的现状及其对目前正在开发的视力恢复疗法的影响。在此，我们讨论视网膜重塑给每种治疗策略带来的挑战和陷阱，前提是全面了解视网膜重塑的特征将提供一个治疗方法可以与之结合的基本框架。此外，我们还讨论了采用可扩散分子与其他视力恢复疗法相结合的联合策略进行治疗的潜力。最后，我们讨论了视网膜和视网膜重塑作为一个模型系统在更广泛地理解中枢神经系统神经退行性变进展方面的潜力。
