甲状腺状态与脂肪组织中的腺苷含量。
Thyroid status and adenosine content of adipose tissue.
作者信息
Ohisalo J J, Stoneham S, Keso L
机构信息
Department of Medical Chemistry, University of Helsinki, Finland.
出版信息
Biochem J. 1987 Sep 1;246(2):555-7. doi: 10.1042/bj2460555.
Abstract
Fat-cells from hypothyroid rats lack the normal lipolytic response to catecholamines. We have suggested that this is due to increased sensitivity to the inhibitory actions of endogenous adenosine. In this paper we present evidence that thyroid hormones increase adipose-tissue adenosine contents and suggest that the increased sensitivity to adenosine in hypothyroidism is due to relief from desensitization by endogenous adenosine.
摘要
甲状腺功能减退大鼠的脂肪细胞对儿茶酚胺缺乏正常的脂解反应。我们认为这是由于对内源性腺苷抑制作用的敏感性增加所致。在本文中，我们提供证据表明甲状腺激素会增加脂肪组织中的腺苷含量，并表明甲状腺功能减退时对腺苷敏感性增加是由于内源性腺苷脱敏作用的解除。
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本文引用的文献
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J Biol Chem. 1964 Feb;239:375-80.
2
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FEBS Lett. 1980 Jun 16;115(1):127-8. doi: 10.1016/0014-5793(80)80741-1.
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Biochem J. 1981 Apr 15;196(1):65-70. doi: 10.1042/bj1960065.
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