腺苷、甲状腺状态与脂肪分解的调节
Adenosine, thyroid status and regulation of lipolysis.
作者信息
Ohisalo J J, Stouffer J E
出版信息
Biochem J. 1979 Jan 15;178(1):249-51. doi: 10.1042/bj1780249.
Abstract
Adipocytes from hypothyroid rats do not respond to adrenaline with increased glycerol release. Adenosine deaminase largely restores lipolytic sensitivity. This effect is reversed by 2-deoxycoformycin, an inhibitor of the enzyme, and by N6-(phenylisopropyl)adenosine, which is not deaminated. Lipolytic response of normal cells to adrenaline is only 50% inhibited by phenylisopropyladenosine, whereas in cells from hypothyroid rats blockage is total. Inhibition of 50% was seen at 100 and 1 nM concentrations respectively. Insensitivity to adrenaline of hypothyroid-rat adipocytes can, at least partly, be explained by increased sensitivity to adenosine.
摘要
甲状腺功能减退大鼠的脂肪细胞对肾上腺素刺激不产生甘油释放增加的反应。腺苷脱氨酶可很大程度上恢复脂解敏感性。该效应可被该酶的抑制剂2-脱氧助间型霉素以及不能被脱氨的N6-（苯异丙基）腺苷逆转。正常细胞对肾上腺素的脂解反应仅被苯异丙基腺苷抑制50%，而甲状腺功能减退大鼠的细胞则完全被阻断。分别在100 nM和1 nM浓度下观察到50%的抑制作用。甲状腺功能减退大鼠脂肪细胞对肾上腺素不敏感至少部分可由对腺苷敏感性增加来解释。
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本文引用的文献
1
Effect of nucleic acid metabolites on lipolysis in adipose tissue.
J Biol Chem. 1961 Dec;236:3125-30.
2
Mode of inhibition of coformycin on adenosine deaminase.
J Antibiot (Tokyo). 1967 Jul;20(4):227-31.
3
Effect of thyroid hormones on epinephrine-induced lipolysis in adipose tissue of rats.
J Biochem. 1971 Jun;69(6):1055-64. doi: 10.1093/oxfordjournals.jbchem.a129558.
4
Hormone-dependent lipolysis in fat-cells from thyroidectomized rats.
Mol Cell Endocrinol. 1974 Oct;1(5):309-27. doi: 10.1016/0303-7207(74)90021-5.
5
Facilitation by adenosine of the action of insulin on the accumulation of adenosine 3':5'-monophosphate, lipolysis, and glucose oxidation in isolated fat cells.
Eur J Biochem. 1974 Aug 1;46(3):537-45. doi: 10.1111/j.1432-1033.1974.tb03647.x.
6
Effects of thyroid hormone deficiency on cyclic adenosine 3':5'-monophosphate and control of lipolysis in fat cells.
J Biol Chem. 1974 Jul 10;249(13):4226-31.
7
Inhibition of adenosine cyclic 3', 5'-monophosphate accumulation in fat cells by adenosine, N6-(phenylisopropyl) adenosine, and related compounds.
Mol Pharmacol. 1973 Sep;9(5):595-604.
8
Studies on the antilipolytic effect of adenosine and related compounds in isolated fat cells.
Naunyn Schmiedebergs Arch Pharmacol. 1973;278(3):247-59. doi: 10.1007/BF00500286.
9
Stimulatory and inhibitory effects of guanyl nucleotides on fat cell adenylate cyclase.
J Biol Chem. 1973 Sep 10;248(17):6239-45.
10
Adenosine release from isolated fat cells and its significance for the effects of hormones on cyclic 3',5'-AMP levels and lipolysis.
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):133-48. doi: 10.1007/BF00501186.
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