Industrial Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Pilani Campus, India.
Expert Opin Drug Deliv. 2023 Jun;20(6):721-738. doi: 10.1080/17425247.2023.2190095. Epub 2023 Mar 13.
For decades, finding effective long-term or disease-modifying treatments for skin disorders has been a major focus of scientists. The conventional drug delivery systems showed poor efficacy with high doses and are associated with side effects, which lead to challenges in adherence to therapy. Therefore, to overcome the limitations of conventional drug delivery systems, drug delivery research has focused on topical, transdermal, and intradermal drug delivery systems. Among all, the dissolving microneedles have gained attention with a new range of advantages of drug delivery in skin disorders such as breaching skin barriers with minimal discomfort and its simplicity of application to the skin, which allows patients to administer it themselves.
This review highlighted the insights into dissolving microneedles for different skin disorders in detail. Additionally, it also provides evidence for its effective utilization in the treatment of various skin disorders. The clinical trial status and patents for dissolving microneedles for the management of skin disorders are also covered.
The current review on dissolving microneedles for skin drug delivery is accentuating the breakthroughs achieved so far in the management of skin disorders. The output of the discussed case studies anticipated that dissolving microneedles can be a novel drug delivery strategy for the long-term treatment of skin disorders.
几十年来，寻找有效且能长期或改善疾病的皮肤疾病治疗方法一直是科学家们的主要关注点。传统的药物输送系统显示出高剂量的疗效不佳，且与副作用相关，这导致了治疗的依从性挑战。因此，为了克服传统药物输送系统的局限性，药物输送研究集中在局部、透皮和皮内药物输送系统上。在所有这些系统中，溶解微针因其在皮肤疾病中的一系列新的药物输送优势而受到关注，例如以最小的不适突破皮肤屏障，以及其简单地应用于皮肤，这允许患者自行给药。
本综述详细介绍了溶解微针对不同皮肤疾病的见解。此外，它还为其在治疗各种皮肤疾病中的有效利用提供了证据。还涵盖了用于治疗皮肤疾病的溶解微针的临床试验现状和专利。
关于溶解微针对皮肤药物输送的最新综述强调了迄今为止在皮肤疾病管理方面取得的突破。所讨论的案例研究的结果预计，溶解微针可以成为治疗皮肤疾病的一种新的药物输送策略。
