School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, P. R. China.
Standardization of Chinese medicine research laboratory, Zhejiang Chinese Medical University, Hangzhou, P. R. China.
Biomed Chromatogr. 2023 Jun;37(6):e5619. doi: 10.1002/bmc.5619. Epub 2023 Mar 22.
You-Gui-Wan is a widely used traditional Chinese medicine preparation for the treatment of osteoporosis with kidney-yang deficiency, and is composed of both yang-invigorating and kidney-tonifying herbs, and yin-nourishing and kidney essence-replenishing herbs. Considering that the pharmacokinetics of drugs might differ in different pathological conditions, it is necessary to study the pharmacokinetic characteristics of You-Gui-Wan under different osteoporotic conditions. In this study, the pharmacokinetic behaviors of You-Gui-Wan in osteoporosis rats with kidney-yin and kidney-yang deficiency were compared. The results showed that the absorption, metabolism, and disposition of You-Gui-Wan varied widely in animals with different types of osteoporosis. The active components belonging to the yang-invigorating herbs, such as aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypacoitine, benzoylmesaconine, chlorogenic acid and pinoresinol diglucoside, had a higher uptake and slower elimination in osteoporosis rats with kidney-yang deficiency, which corresponds to the opinion that You-Gui-Wan is used to treat kidney-yang deficiency syndrome, and indicates the scientific nature of Bian-Zheng-Lun-Zhi.
右归丸是一种广泛用于治疗肾阳虚型骨质疏松症的中药方剂，由补肾阳和补肾精的草药以及滋阴补肾的草药组成。由于药物在不同病理条件下的药代动力学可能不同，因此有必要研究不同骨质疏松症条件下右归丸的药代动力学特征。在这项研究中，比较了肾阳虚型和肾阴虚型骨质疏松症大鼠的右归丸药代动力学行为。结果表明，不同类型骨质疏松症动物的右归丸吸收、代谢和处置差异很大。属于补肾阳草药的活性成分，如乌头碱、次乌头碱、新乌头碱、苯甲酰乌头碱、苯甲酰次乌头碱、苯甲酰新乌头碱、绿原酸和松脂醇二葡萄糖苷，在肾阳虚型骨质疏松症大鼠中吸收更多，消除更慢，这与右归丸用于治疗肾阳虚证的观点一致，表明了辨证论治的科学性。
