Proux J P, Miller C A, Li J P, Carney R L, Girardie A, Delaage M, Schooley D A
Laboratoire de Neuroendocrinologie, UA CNRS 1138, Université de Bordeaux I, Talence, France.
Biochem Biophys Res Commun. 1987 Nov 30;149(1):180-6. doi: 10.1016/0006-291x(87)91621-4.
We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biological role is unknown. The less abundant factor, F2, is an antiparallel dimer of F1, and functions as a diuretic hormone of this species. It appears to act through the intermediacy of cyclic AMP. The properties of the native neuropeptides were identical with those of samples synthesized from appropriately protected L-amino acids.
我们从飞蝗的咽下神经节和胸神经节中鉴定出了两种神经肽（F1和F2），我们之前基于它们与精氨酸加压素的免疫相似性将其分离出来。含量较多且具有亲水性的因子F1，其序列为Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2，但其生物学作用尚不清楚。含量较少的因子F2是F1的反平行二聚体，作为该物种的利尿激素发挥作用。它似乎通过环磷酸腺苷起作用。天然神经肽的性质与由适当保护的L-氨基酸合成的样品的性质相同。
