Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Department of Radiation Medicine and Applied Sciences, University of California, San Diego, California, USA.
Clin Oncol (R Coll Radiol). 2023 Aug;35(8):507-515. doi: 10.1016/j.clon.2023.02.010. Epub 2023 Feb 23.
Skin brachytherapy represents an excellent alternative treatment for patients with non-melanoma skin cancers. It offers superior conformity of dose distribution with rapid dose fall off, reducing the risk of radiotherapy-related treatment toxicity. A smaller treatment volume in brachytherapy, when compared with external beam radiotherapy, is conducive for hypofractionation, which is an attractive option for decreasing outpatient visits to the cancer centre, especially for elderly and frail patients. Skin brachytherapy is an excellent option to preserve function and cosmesis, especially in skin cancers located in the head and neck region. Electronic brachytherapy, image-guided superficial brachytherapy and 3D printed moulds are all emerging advances in skin brachytherapy.
皮肤近距离放射治疗是治疗非黑色素瘤皮肤癌的一种极好的替代疗法。它提供了卓越的剂量分布一致性，剂量迅速下降，降低了放疗相关治疗毒性的风险。与外部束放疗相比，近距离放疗的治疗体积较小，有利于分割治疗，这对于减少癌症中心的门诊就诊次数是一个有吸引力的选择，特别是对于老年和体弱患者。皮肤近距离放射治疗是保留功能和美容的极好选择，特别是在头颈部皮肤癌的治疗中。电子近距离放射治疗、图像引导浅层近距离放射治疗和 3D 打印模具都是皮肤近距离放射治疗的新兴进展。
