Matsuda M, Miyahara T, Murai A, Fujimoto N, Kameyama M
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.
Atherosclerosis. 1987 Nov;68(1-2):131-6. doi: 10.1016/0021-9150(87)90103-1.
Serum lipid and apolipoprotein concentrations were measured in 37 male survivors of cerebral infarction (CI) and in 30 healthy controls. Both groups had similar total cholesterol levels, but the HDL-cholesterol level was significantly lower and the serum triglyceride level was significantly higher in the CI patients than in the controls. The ApoB level was significantly higher in the CI patients but there was no significant difference between the 2 groups in the levels of the other apolipoproteins (ApoA-I, A-II, C-II, C-III, and E). The HDL-cholesterol/ApoA-I ratio was significantly lower in the CI patients. Both the VLDL-triglyceride and VLDL-cholesterol levels were higher in the CI patients but the VLDL-cholesterol especially its cholesterol ester level was conspicuously high. A population of VLDL particles that bound to heparin on heparin-Sepharose columns was increased in the CI patients. We suggest that cholesterol ester is excessively transferred from HDL to VLDL during the disturbed catabolism of VLDL in CI patients.
对37名男性脑梗死（CI）幸存者和30名健康对照者的血清脂质和载脂蛋白浓度进行了测量。两组的总胆固醇水平相似，但CI患者的高密度脂蛋白胆固醇水平显著低于对照组，血清甘油三酯水平显著高于对照组。CI患者的载脂蛋白B水平显著更高，但两组在其他载脂蛋白（载脂蛋白A-I、A-II、C-II、C-III和E）水平上无显著差异。CI患者的高密度脂蛋白胆固醇/载脂蛋白A-I比值显著更低。CI患者的极低密度脂蛋白甘油三酯和极低密度脂蛋白胆固醇水平均更高，但极低密度脂蛋白胆固醇尤其是其胆固醇酯水平明显升高。CI患者中与肝素-琼脂糖柱上的肝素结合的极低密度脂蛋白颗粒群体增加。我们认为，在CI患者极低密度脂蛋白分解代谢紊乱期间，胆固醇酯从高密度脂蛋白过度转移至极低密度脂蛋白。
