Ruan Guangfeng, Lu Shilong, Zhang Yan, Zhu Zhaohua, Cao Peihua, Wang Xiaoshuai, Li Jia, Tang Su'an, Chen Tianyu, Han Weiyu, Zhu Jianwei, Chen Di, Antony Benny, Winzenberg Tania, Wluka Anita E, Cicuttini Flavia, Ding Changhai
Zhujiang Hospital Clinical Research Centre Guangzhou China.
Zhujiang Hospital Imaging Diagnosis Department Guangzhou China.
Curr Med Imaging. 2023 Mar 10. doi: 10.2174/1573405619666230310093402.
The objective of this study is to investigate whether quantitatively measured infrapatellar fat pad (IPFP) signal intensity alteration is associated with joint effusion-synovitis in people with knee osteoarthritis (OA) over two years.
Among 255 knee OA patients, IPFP signal intensity alteration represented by four measurement parameters [standard deviation of IPFP signal intensity (IPFP sDev), upper quartile value of IPFP high signal intensity region (IPFP UQ (H)), ratio of IPFP high signal intensity region volume to whole IPFP volume (IPFP percentage (H)), and clustering factor of IPFP high signal intensity (IPFP clustering factor (H))] was measured quantitatively at baseline and two-year follow-up using magnetic resonance imaging (MRI). Effusion-synovitis of the suprapatellar pouch and other cavities were measured both quantitatively and semi-quantitatively as effusion-synovitis volume and effusion-synovitis score at baseline and two-year follow-up using MRI. Mixed effects models assessed the associations between IPFP signal intensity alteration and effusion-synovitis over two years.
In multivariable analyses, all four parameters of IPFP signal intensity alteration were positively associated with total effusion-synovitis volume and effusion-synovitis volumes of the suprapatellar pouch and of other cavities over two years (all P＜0.05). They were also associated with the semi-quantitative measure of effusion-synovitis except for IPFP percentage (H) with effusion-synovitis in other cavities.
Quantitatively measured IPFP signal intensity alteration is positively associated with joint effusion-synovitis in people with knee OA, suggesting that IPFP signal intensity alteration may contribute to effusion-synovitis and a coexistent pattern of these two imaging biomarkers could exist in knee OA patients.
本研究旨在调查在两年时间里，定量测量的髌下脂肪垫（IPFP）信号强度改变是否与膝关节骨关节炎（OA）患者的关节积液 - 滑膜炎相关。
在255例膝关节OA患者中，通过四个测量参数[IPFP信号强度标准差（IPFP sDev）、IPFP高信号强度区域的上四分位数（IPFP UQ (H)）、IPFP高信号强度区域体积与整个IPFP体积之比（IPFP百分比 (H)）以及IPFP高信号强度的聚类因子（IPFP聚类因子 (H)）]来表示的IPFP信号强度改变，在基线和两年随访时使用磁共振成像（MRI）进行定量测量。髌上囊和其他腔隙的积液 - 滑膜炎在基线和两年随访时使用MRI分别作为积液 - 滑膜炎体积和积液 - 滑膜炎评分进行定量和半定量测量。混合效应模型评估了两年内IPFP信号强度改变与积液 - 滑膜炎之间的关联。
在多变量分析中，IPFP信号强度改变的所有四个参数在两年内均与总积液 - 滑膜炎体积、髌上囊和其他腔隙的积液 - 滑膜炎体积呈正相关（所有P＜0.05）。除了IPFP百分比 (H)与其他腔隙的积液 - 滑膜炎外，它们还与积液 - 滑膜炎的半定量测量相关。
定量测量的IPFP信号强度改变与膝关节OA患者的关节积液 - 滑膜炎呈正相关，这表明IPFP信号强度改变可能导致积液 - 滑膜炎，并提示这两种影像学生物标志物在膝关节OA患者中可能存在共存模式。
