Institute of Geriatrics, the Affiliated Hospital of Medical School.
Department of Preventive Medicine, School of Medicine, Ningbo University, Ningbo, China.
Rheumatology (Oxford). 2022 Dec 23;62(1):439-449. doi: 10.1093/rheumatology/keac214.
To explore the longitudinal association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with OA-related biomarkers.
Eighteen OA-related biochemical biomarkers of 600 knee OA participants in the Foundation for the National Institutes of Health OA Biomarkers Consortium (FNIH) study were extracted. The quantitative IPFP signal intensity measures were acquired based on magnetic resonance imaging, including mean value [Mean (IPFP)] and standard deviation [sDev (IPFP)] of the whole IPFP signal intensity, median value [Median (H)] and upper quartile value [UQ (H)] of high signal intensity, the ratio of volume of high signal intensity to volume of whole IPFP signal intensity [Percentage (H)] and Clustering factor (H). The linear mixed-effect model was applied to determine the longitudinal associations between IPFP signal intensity alteration and biochemical biomarkers over 2 years.
All IPFP measures except for Clustering factor (H) were positively associated with urine collagenase-cleaved type II collagen neoepitope (uC2C), urine C-terminal cross-linked telopeptide of type II collagen (uCTX-II), urine C-terminal cross-linked telopeptide of type I collagen-α (uCTX-Iα) and urine N-terminal cross-linked telopeptide of type I collagen (uNTX-I). Mean (IPFP), Median (H) and Percentage (H) were positively associated with the nitrated form of an epitope located in the triple helix of type II collagen (Coll2-1 NO2). Mean (IPFP), Median (H) and UQ (H) were positively associated with sCTX-I and uCTX-Iβ. Positive associations between sDev (IPFP), Percentage (H) and serum hyaluronic acid (sHA) were found.
Our results suggest a role of IPFP signal intensity alteration in joint tissue remodelling on a molecular level.
探索髌下脂肪垫（IPFP）定量信号强度改变与 OA 相关生物标志物的纵向关联。
从国立卫生研究院 OA 生物标志物联盟（FNIH）研究的 600 名膝骨关节炎患者中提取了 18 项 OA 相关生化生物标志物。基于磁共振成像获得了 IPFP 信号强度的定量测量值，包括整个 IPFP 信号强度的平均值[Mean（IPFP）]和标准偏差[sDev（IPFP）]、高信号强度的中位数[Median（H）]和上四分位数值[UQ（H）]、高信号强度体积与整个 IPFP 信号强度体积的比值[百分比（H）]和聚类因子（H）。应用线性混合效应模型确定 2 年内 IPFP 信号强度改变与生化标志物之间的纵向关联。
除聚类因子（H）外，所有 IPFP 指标均与尿液胶原酶裂解型 II 型胶原新表位（uC2C）、尿液 II 型胶原 C 端交联肽（uCTX-II）、尿液 I 型胶原 α 端 C 端交联肽（uCTX-Iα）和尿液 I 型胶原 N 端交联肽（uNTX-I）呈正相关。Mean（IPFP）、Median（H）和 Percentage（H）与位于 II 型胶原三螺旋结构中的一个表位的硝化形式呈正相关（Coll2-1 NO2）。Mean（IPFP）、Median（H）和 UQ（H）与 sCTX-I 和 uCTX-Iβ呈正相关。sDev（IPFP）、Percentage（H）和血清透明质酸（sHA）之间存在正相关。
我们的研究结果表明，IPFP 信号强度改变在分子水平上与关节组织重塑有关。
