Arthritis Research Institute, Department of Rheumatology, 1st Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Arthritis Research Institute, Department of Rheumatology, 1st Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Osteoarthritis Cartilage. 2018 Oct;26(10):1345-1350. doi: 10.1016/j.joca.2018.05.015. Epub 2018 May 26.
To investigate whether infrapatellar fat pad (IPFP) signal intensity (SI) alteration predicts the occurrence of knee replacement (KR) in knee osteoarthritis (OA) patients over 5 years.
The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. They were matched by gender, age and radiographic status with control knees (n = 127). We used T2-weighted MR images to measure IPFP SI alteration using a newly developed algorithm in MATLAB. The measurements were assessed at baseline (BL), T0 (the visit just before KR) and 1 year before T0 (T-1). Conditional logistic regression was used to analyse the associations between IPFP SI alterations and the risk of KR.
Participants were mostly female (57%), with an average age of 63.7 years old and a mean body mass index (BMI) of 29.5 kg/m. In multivariable analysis, the standard deviation (SD) of IPFP SI [sDev (IPFP)] and the ratio of high SI region volume to whole IPFP volume [Percentage (H)] measured at BL were significantly associated with increased risks of KR after adjustment for covariates. IPFP SI alterations measured at T-1 including sDev (IPFP), Percentage (H) and clustering effect of high SI [Clustering factor (H)] were significantly associated with higher risks of KR. All measurements were significantly associated with higher risks of KR at T0.
IPFP SI is associated with the occurrence of KR suggesting it may play a role in end-stage knee OA.
探讨髌下脂肪垫（IPFP）信号强度（SI）改变是否能预测膝骨关节炎（OA）患者在 5 年内行膝关节置换术（KR）的发生。
本研究对象选自骨关节炎倡议（OAI）研究。病例组（n=127）定义为在 5 年随访中接受 KR 的膝关节。通过性别、年龄和影像学状态与对照组（n=127）相匹配。我们使用 T2 加权 MR 图像，采用新开发的 MATLAB 算法来测量 IPFP SI 改变。在基线（BL）、T0（即 KR 前的就诊时）和 T0 前 1 年（T-1）时进行测量。采用条件逻辑回归分析 IPFP SI 改变与 KR 风险之间的关系。
参与者主要为女性（57%），平均年龄 63.7 岁，平均体重指数（BMI）为 29.5kg/m。多变量分析显示，BL 时 IPFP SI 的标准差（sDev（IPFP））和高 SI 区体积与整个 IPFP 体积的比值[百分比（H）]与校正混杂因素后的 KR 风险增加显著相关。T-1 时测量的 IPFP SI 改变包括 sDev（IPFP）、Percentage（H）和高 SI 的聚类效应[聚类因子（H）]与 KR 风险增加显著相关。所有测量指标在 T0 时与 KR 风险增加显著相关。
IPFP SI 与 KR 的发生有关，提示其可能在终末期膝骨关节炎中起作用。
