Liu Xin, Qiu Xiaoyu, Yang Yong, Wang Jing, Wang Qi, Liu Jingbo, Yang Feiyun, Liu Zuohua, Qi Renli
Chongqing Academy of Animal Science, Chongqing 402460, China.
College of Animal Science and Technology, Southwest University, Chongqing 402460, China.
iScience. 2023 Feb 13;26(3):106190. doi: 10.1016/j.isci.2023.106190. eCollection 2023 Mar 17.
This study evaluated the repair effects of (CBX 2021) on the antibiotic (ABX)-induced intestinal dysbiosis in mice by the multi-omics method. Results showed that ABX eliminated more than 90% of cecal bacteria and also exerted adverse effects on the intestinal structure and overall health in mice after 10 days of the treatment. Of interest, supplementing CBX 2021 in the mice for the next 10 days colonized more butyrate-producing bacteria and accelerated butyrate production compared with the mice by natural recovery. The reconstruction of intestinal microbiota efficiently promoted the improvement of the damaged gut morphology and physical barrier in the mice. In addition, CBX 2021 significantly reduced the content of disease-related metabolites and meanwhile promoted carbohydrate digestion and absorption in mice followed the microbiome alternation. In conclusion, CBX 2021 can repair the intestinal ecology of mice damaged by the antibiotics through reconstructing gut microbiota and optimizing metabolic functions.
本研究采用多组学方法评估了（CBX 2021）对抗生素（ABX）诱导的小鼠肠道菌群失调的修复作用。结果显示，ABX处理10天后，消除了超过90%的盲肠细菌，并且对小鼠的肠道结构和整体健康产生了不利影响。有趣的是，在接下来的10天里给小鼠补充CBX 2021，与自然恢复的小鼠相比，定殖了更多的产丁酸菌并加速了丁酸的产生。肠道微生物群的重建有效地促进了受损肠道形态和小鼠物理屏障的改善。此外，CBX 2021显著降低了疾病相关代谢物的含量，同时随着微生物群的改变促进了小鼠碳水化合物的消化和吸收。总之，CBX 2021可以通过重建肠道微生物群和优化代谢功能来修复抗生素损伤的小鼠肠道生态。
