Suzhou Municipal Center for Disease Control and Prevention, Suzhou, China.
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Front Public Health. 2023 Feb 21;11:1084840. doi: 10.3389/fpubh.2023.1084840. eCollection 2023.
This study aimed to examine the real prevalence of late presentation of HIV infection and to identify factors associated with late HIV presentation among patients with newly diagnosed HIV/AIDS in Suzhou, China.
Patients with newly diagnosed HIV/AIDS who registered in national AIDS surveillance system from 2017 to 2020 were included in this study. Late presentation (LP) of HIV infection was defined as HIV diagnosis with a CD4 count < 350 cells/μL or an AIDS-defining event. Multivariable logistic regression analyses were used to identify factors associated with LP.
A total of 2,300 patients were enrolled. 1,325 were classified as late presenters, showing a high percentage of 57.6% (95% CI: 54.5-60.7%) and a rise ( = 0.004) over the four-year period. Patients with newly diagnosed HIV/AIDS who were older than 24 years of age (aOR = 1.549, = 0.001 for 25-39 years; aOR = 2.389, < 0.001 for 40 years and older), were Suzhou registered residents (aOR = 1.259, = 0.026), and were from inpatient and outpatient (aOR = 1.935, < 0.001) were more likely to be late presentation.
This study showed a high percentage and a rise of late presentation of HIV infection among patients with newly diagnosed HIV/AIDS in Suzhou, China, which is a challenge for future prevention and control of AIDS. Targeted measures should be urgently implemented to reduce late HIV diagnosis.
本研究旨在调查中国苏州新诊断 HIV/AIDS 患者中 HIV 感染晚期表现的真实流行率，并确定与晚期 HIV 表现相关的因素。
本研究纳入了 2017 年至 2020 年在中国国家艾滋病监测系统中登记的新诊断 HIV/AIDS 患者。晚期 HIV 感染定义为 CD4 计数<350 个/μL 或出现艾滋病定义性事件时诊断 HIV。采用多变量逻辑回归分析确定与晚期表现相关的因素。
共纳入 2300 例患者，其中 1325 例为晚期表现患者，占比高达 57.6%（95%CI：54.5-60.7%），且在四年期间呈上升趋势（ = 0.004）。年龄大于 24 岁（25-39 岁：aOR=1.549， = 0.001；40 岁及以上：aOR=2.389， < 0.001）、苏州户籍（aOR=1.259， = 0.026）、住院和门诊（aOR=1.935， < 0.001）的新诊断 HIV/AIDS 患者更有可能为晚期表现。
本研究表明，中国苏州新诊断 HIV/AIDS 患者中晚期 HIV 感染的比例和上升幅度较高，这对未来艾滋病的防控构成挑战。应紧急实施有针对性的措施，以减少晚期 HIV 诊断。
