Makkonen T A, Nordman E
Department of Oral Surgery, University of Turku, Finland.
Acta Oncol. 1987;26(4):307-12. doi: 10.3109/02841868709089980.
A classification is proposed for estimating salivary gland damage induced by radiotherapy to the head and neck. The volume of salivary glands irradiated was evaluated, and their relative proportions of whole saliva output were calculated. Stimulated salivary flow rate was measured in 61 patients treated with radiotherapy for head and neck malignancies. A highly significant negative correlation was found between the classification of salivary gland damage and stimulated salivary flow rate. The volume of the major salivary glands irradiated seems to be the most important factor affecting the postirradiation salivary flow after a curative dose of radiotherapy. If possible, partial sparing of the salivary glands may help to keep the patient's salivary secretion at an acceptable level and promote protection against dental caries. Most patients irradiated to the head and neck, however, need an effective prophylactic programme for the rest of their lives in order to preserve their teeth.
本文提出了一种用于评估头颈部放疗所致唾液腺损伤的分类方法。评估了受照射唾液腺的体积，并计算其在全唾液分泌量中的相对占比。对61例接受头颈部恶性肿瘤放疗的患者测量了刺激唾液流速。发现唾液腺损伤分类与刺激唾液流速之间存在高度显著的负相关。在给予根治性放疗剂量后，受照射的主要唾液腺体积似乎是影响放疗后唾液流速的最重要因素。如果可能，部分保留唾液腺或许有助于使患者的唾液分泌维持在可接受水平，并促进预防龋齿。然而，大多数接受头颈部放疗的患者为了保护牙齿，余生都需要有效的预防性方案。
