Inoguchi Yohei, Hatano Koji, Kato Taigo, Kawashima Atsunari, Abe Toyofumi, Fukuhara Shinichiro, Uemura Motohide, Kiuchi Hiroshi, Imamura Ryoichi, Nonomura Norio
Department of Urology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
Int Cancer Conf J. 2022 Dec 29;12(2):115-119. doi: 10.1007/s13691-022-00589-0. eCollection 2023 Apr.
Vascular leiomyosarcoma of the inferior vena cava is a rare malignant soft tissue tumor that requires surgical treatment to prevent tumor-related symptoms such as pulmonary embolism and Budd-Chiari syndrome. However, a treatment strategy for surgical resection of advanced cases has not yet been determined. This report describes the case of advanced leiomyosarcoma of the inferior vena cava that was successfully treated with surgery and subsequent chemotherapy. A 44-year-old man was found to have a 12 × 10 cm retroperitoneal tumor on computed tomography. The tumor originated in the inferior vena cava and extended beyond the diaphragm into the renal vein. The surgical plan was determined in joint consultation with the multidisciplinary team. It was safely resected and the inferior vena cava was closed caudal to the porta hepatis without a synthetic graft. The tumor was diagnosed as leiomyosarcoma. Doxorubicin, followed by pazopanib were administered as treatment for metastatic disease. Eighteen months after the surgery, the patient's performance status was maintained.
下腔静脉血管平滑肌肉瘤是一种罕见的恶性软组织肿瘤，需要进行手术治疗以预防肿瘤相关症状，如肺栓塞和布加综合征。然而，晚期病例的手术切除治疗策略尚未确定。本报告描述了一例晚期下腔静脉平滑肌肉瘤患者，通过手术及后续化疗成功治愈。一名44岁男性在计算机断层扫描中发现有一个12×10厘米的腹膜后肿瘤。肿瘤起源于下腔静脉，延伸至膈肌上方进入肾静脉。手术方案是在多学科团队的联合会诊后确定的。肿瘤被安全切除，下腔静脉在肝门下方封闭，未使用人工血管移植。肿瘤被诊断为平滑肌肉瘤。使用阿霉素，随后使用帕唑帕尼治疗转移性疾病。手术后18个月，患者的身体状况得以维持。
