文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zantvoort F A, Wagenvoort J H, Derkx F H, Michel M F

Department of Clinical Pharmacology, University Hospital Dykzigt, Rotterdam, The Netherlands.

Br J Clin Pharmacol. 1987 Oct;24(4):511-8. doi: 10.1111/j.1365-2125.1987.tb03205.x.

Several nomograms and computer programs are available to aid in aminoglycoside dosing. 2. Due to the variability in the relationship between dosage and serum drug levels, monitoring through the acquisition of serum drug levels is mandatory. 3. All clinical data, including serum drug levels, are subject to errors. 4. The program we have evaluated, OPT, calculates the most likely set of pharmacokinetic parameter estimates for individual patients by applying Bayes' theorem and the principle of Maximum Likelihood Estimation. Through a feedback process all available data are used, taking possible errors into account. 5. Our study shows that OPT is able to predict serum aminoglycoside levels accurately in the routine clinical setting. It may thus contribute to the quality of aminoglycoside therapy.

有几种列线图和计算机程序可用于辅助氨基糖苷类药物的给药剂量计算。2. 由于剂量与血清药物水平之间关系的变异性，通过获取血清药物水平进行监测是必不可少的。3. 所有临床数据，包括血清药物水平，都可能存在误差。4. 我们评估的程序OPT，通过应用贝叶斯定理和最大似然估计原理，为个体患者计算最可能的一组药代动力学参数估计值。通过反馈过程，利用所有可用数据，并考虑到可能的误差。5. 我们的研究表明，OPT能够在常规临床环境中准确预测血清氨基糖苷类药物水平。因此，它可能有助于提高氨基糖苷类药物治疗的质量。

Zantvoort F A, Wagenvoort J H, Derkx F H, Michel M F

Department of Clinical Pharmacology, University Hospital Dykzigt, Rotterdam, The Netherlands.

Br J Clin Pharmacol. 1987 Oct;24(4):511-8. doi: 10.1111/j.1365-2125.1987.tb03205.x.

Several nomograms and computer programs are available to aid in aminoglycoside dosing. 2. Due to the variability in the relationship between dosage and serum drug levels, monitoring through the acquisition of serum drug levels is mandatory. 3. All clinical data, including serum drug levels, are subject to errors. 4. The program we have evaluated, OPT, calculates the most likely set of pharmacokinetic parameter estimates for individual patients by applying Bayes' theorem and the principle of Maximum Likelihood Estimation. Through a feedback process all available data are used, taking possible errors into account. 5. Our study shows that OPT is able to predict serum aminoglycoside levels accurately in the routine clinical setting. It may thus contribute to the quality of aminoglycoside therapy.

有几种列线图和计算机程序可用于辅助氨基糖苷类药物的给药剂量计算。2. 由于剂量与血清药物水平之间关系的变异性，通过获取血清药物水平进行监测是必不可少的。3. 所有临床数据，包括血清药物水平，都可能存在误差。4. 我们评估的程序OPT，通过应用贝叶斯定理和最大似然估计原理，为个体患者计算最可能的一组药代动力学参数估计值。通过反馈过程，利用所有可用数据，并考虑到可能的误差。5. 我们的研究表明，OPT能够在常规临床环境中准确预测血清氨基糖苷类药物水平。因此，它可能有助于提高氨基糖苷类药物治疗的质量。