Center of Bioscience, Institute for Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovakia.
Gen Physiol Biophys. 2023 Mar;42(2):107-122. doi: 10.4149/gpb_2023001.
Major depressive disorder is a very common serious mental illness with increasing prevalence in the population. Its pathology includes biochemical, morphological, and electrophysiological changes in various brain areas. In spite of decades of extensive research pathophysiology of depression is still not sufficiently understood. When depression occurs just before or during pregnancy, it may have a detrimental effect on perinatal and/or postnatal brain development, affecting the offspring's behavior. An important role in the pathology of depression is the hippocampus as a center for cognition and memory. Here we review changes in morphology, biochemical, and electrical signaling caused by depression in first and second generation identified in various animal models.
重度抑郁症是一种非常常见的严重精神疾病，其在人群中的患病率不断增加。其病理学包括各种脑区的生化、形态和电生理变化。尽管经过几十年的广泛研究，抑郁症的发病机制仍未得到充分理解。当抑郁症发生在怀孕前或怀孕期间时，可能会对围产期和/或产后大脑发育产生不利影响，从而影响后代的行为。在抑郁症的发病机制中，海马体作为认知和记忆的中心起着重要作用。在这里，我们综述了各种动物模型中第一代和第二代抑郁症引起的形态、生化和电信号变化。
